27 papers · ranked by Valyu relevance
Bin Wang, Olga K Dudko, Timothy E Behrens, Timothy E Behrens
Rapid and precise neuronal communication is enabled through a highly synchronous release of signaling molecules neurotransmitters within just milliseconds of the action potential. Yet neurotransmitter release lacks a theoretical framework that is both phenomenologically accurate and mechanistically realistic. Here, we…
James Scully, Jassem Bourahmah, David Bloom, Andrey L. Shilnikov
In this study we focus on two subnetworks common in the circuitry of swim central pattern generators (CPGs) in the sea slugs, Melibe leonina and Dendronotus iris and show that they are independently capable of stably producing emergent network bursting. This observation raises the question of whether the coordination…
Qiang Yu, Misha Tsodyks, Haim Sompolinsky, Dietmar Schmitz + 1 more
Title: Significance Neurons in the brain communicate through spikes that are transmitted via chemical synapses that express both long-term and short-term plasticity. While long-term plasticity is thought to be the central site of learning and memory and has dominated research, its interactions with short-term…
Keivan Moradi, Zainab Aldarraji, Megha Luthra, Grey P. Madison + 1 more
Biologically realistic computer simulations of neuronal circuits require systematic data-driven modeling of neuron type-specific synaptic activity. However, limited experimental yield, heterogeneous recordings conditions, and ambiguous neuronal identification have so far prevented the consistent characterization of…
Paulo R. Protachevicz, Antonio M. Batista, Iberê L. Caldas, Murilo S. Baptista
Synaptic dynamics plays a key role in neuronal communication. Due to its high-dimensionality, the main fundamental mechanisms triggering different synaptic dynamics and its relation with the neurotransmitters release regimes (facilitation, biphasic, and depression) are still elusive. For a general set of parameters…
Saray Soldado-Magraner, Jamie McDowell, Shanglin Zhou, Dean V. Buonomano
In computational neuroscience and deep learning models, synapses are viewed as simple computational elements with a single learnable parameter: synaptic strength. Here we propose that synapses are more sophisticated elements with multiple learnable parameters; allowing synapses to tune their short-term synaptic…
Francesco Negri, Jannik Luboeinski, Christian Tetzlaff, Michael Fauth
According to the synaptic tagging-and-capture hypothesis, long-term synaptic plasticity requires postsynaptic sites to establish a synaptic tag, enabling them to capture plasticity-related products synthesized elsewhere in the neuron. Although electrophysiological studies have provided evidence for the existence of…
Thi Kim Thoa Thieu, Roderick Melnik
> Abstract. Working memory (WM) has been intensively used to enable the temporary storing of information for processing purposes, playing an important role in the execution of various cognitive tasks. Recent studies have shown that information in WM is not only maintained through persistent recurrent activity but also…
Christopher A Norman, Shyam S Krishnakumar, Yulia Timofeeva, Kirill E Volynski
'Kirill E Volynski'] Calcium-evoked release of neurotransmitters from synaptic vesicles (SVs) is catalysed by SNARE proteins. The predominant view is that, at rest, complete assembly of SNARE complexes is inhibited (‘clamped’) by synaptotagmin and complexin molecules. Calcium binding by synaptotagmins releases this…
Chelsy R. Eddings, Shigeki Watanabe
Neural circuitry depends on excitatory and inhibitory regulation of activity to yield functional outputs. However, examinations of synaptic vesicle recycling have focused heavily on excitatory synapses, leaving many questions unanswered for inhibitory synapse dynamics. Here we show that both excitatory and inhibitory…
Sat byul Seo, Jianzhong Su
A synapse acts on neural transmission through a chemical process called synapses fusion between pre-synaptic and post-synaptic terminals. Presynaptic terminals release neurotransmitters either in response to action potential or spontaneously independent of presynaptic activity. However, it is still unclear the…
Stefano Fusi
Memory is a complex phenomenon that involves several distinct mechanisms. These mechanisms operate at different spatial and temporal levels. This chapter focuses on the theoretical framework and the mathematical models that have been developed to understand how these mechanisms are orchestrated to store, preserve and…
Cian O’Donnell
Learning and memory relies on synapses changing their strengths in response to neural activity. However there is a substantial gap between the timescales of neural electrical dynamics (1—100 ms) and organism behaviour during learning (seconds—minutes). What mechanisms bridge this timescale gap? What are the…
Yuanmo Wang, Ajay Pradhan, Pankaj Gupta, Jörg Hanrieder + 2 more
Acetylcholine (ACh) is a critical neurotransmitter influencing various neurophysiological functions. Despite its significance, there is a lack of quantitative methods with adequate spatiotemporal resolution for recording single exocytotic efflux of ACh. In this study, we present an ultrafast amperometric ACh biosensor…
Grit Bornschein, Simone Brachtendorf, Abdelmoneim Eshra, Robert Kraft + 3 more
Synaptotagmin 1 (Syt1) and Syt2 are the main Ca^2+^ sensors triggering synchronous release in the brain. The Ca^2+^-sensitivity of Syt2-triggered release has been studied in detail. However, for Syt1, the dominating isoform in the neocortex, quantitative detail is lacking. We measured the Ca^2+^-dependency of…
Felicitas Bruentgens, Laura Moreno Velasquez, Alexander Stumpf, Daniel Parthier + 5 more
Synapsins are highly abundant presynaptic proteins that play a crucial role in neurotransmission and plasticity via the clustering of synaptic vesicles. The synapsin III isoform is usually downregulated after development, but in hippocampal mossy fiber boutons it persists in adulthood. Mossy fiber boutons express…
Chelsy R. Eddings, Minghua Fan, Yuuta Imoto, Kie Itoh + 7 more
Title: Summary Live human brain tissues provide unique opportunities for understanding synaptic transmission. Investigations have been limited to anatomy, electrophysiology, and protein localization-while crucial parameters such as synaptic vesicle dynamics were not visualized. Here we utilize zap-and-freeze…
James H. Scully, Jassem Bourahmah, David E. Bloom, Andrey Shilnikov
The purpose of this paper is trifold – to serve as an instructive resource and a reference catalog for biologically plausible modeling with i) conductance-based models, coupled with ii) strength-varying slow synapse models, culminating in iii) two canonical pair-wise rhythm-generating networks. We document the…
Yuanhong Tang, Shanshan Jia, Tiejun Huang, Zhaofei Yu + 1 more
neuron Authors: ['Yuanhong Tang' 'Shanshan Jia' 'Tiejun Huang' 'Zhaofei Yu' 'Jian K. Liu'] A single neuron receives an extensive array of synaptic inputs through its dendrites, raising the fundamental question of how these inputs undergo integration and summation, culminating in the initiation of spikes in the soma.…
Yoichi Araki, Kacey E. Rajkovich, Elizabeth E. Gerber, Timothy R. Gamache + 6 more
SynGAP is an abundant synaptic GTPase-activating protein (GAP) critical for synaptic plasticity, learning, memory, and cognition. Mutations in SYNGAP1 in humans result in intellectual disability, autistic-like behaviors, and epilepsy. Heterozygous Syngap1 knockout mice display deficits in synaptic plasticity, learning…
Authors not listed
Acetylcholine (ACh) is a key neurotransmitter involved in cognitive function, motor control, and synaptic modulation, yet its electrochemical inactivity and the rapid kinetics of exocytosis have hindered real-time quantal detection. Previous micrometer-scale enzymatic ACh biosensors enabled sub-millisecond…
Daniel Trpevski, Jeanette Hellgren Kotaleski, Matthias Hennig
Inhibitory synapses can control a neuron’s firing rate and also control supralinear dendritic integration. It is not known how inhibitory synapses can learn to perform these functions using only signals available locally at the synaptic site. We study an inhibitory plasticity rule based on the Bienenstock-Cooper-Munro…
Afsaneh Taheri Kal-Koshvandi
We present the first light-free, genetically minimal platform for spatiotemporally resolved proximity labeling across five neuronal compartments—synaptic, nuclear, endosomal, mitochondrial, and activity-dependent microdomains. A covalent "catalyst–luciferase sandwich" architecture site-specifically conjugates five…
Authors not listed
Researching the EEEV virus is challenging due to the virus's high lethality and significant risk. This study employed bioinformatics methods for domain search to investigate the pathogenesis and infection process of the EEEV virus P protein. The results demonstrated that the EEEV virus P protein contains domains that…
Authors not listed
The GluK1 receptor, an ionotropic glutamate receptor, operates as a ligand-gated ion channel. Opioids stand as the most potent pain-relieving medications currently prescribed in the medical field. Inhibiting this receptor is anticipated to result in a reduction of dopamine release in the Nucleus Accumbens, effectively…
wenzhong liu, hualan li
Infection with the Zika virus results in severe neurological disease in adults or congenital Zika syndrome in newborns. We employed the domain search strategy to study the Zika virus glycoprotein E in this work. The results revealed that immature E contains a NGF domain…
Authors not listed
Membrane fusion underpins many fundamental cellular processes, yet the design of artificial fusogens that can interact with specific cell surface markers in a precise and predictable manner remains a major challenge. Here we demonstrate that cholera toxin B-subunit (CTB), a naturally occurring glycolipid-binding…