24 papers · ranked by Valyu relevance
Savanna-Rae H Fahoum, Dawn M Blitz
Oscillatory networks underlying rhythmic motor behaviors, and sensory and complex neural processing, are flexible, even in their neuronal composition. Neuromodulatory inputs enable neurons to switch participation between networks, or participate in multiple networks simultaneously. Neuromodulation of internetwork…
Kenneth J. Burke Jr., Kevin J. Bender
The axon is responsible for integrating synaptic signals, generating action potentials (APs), propagating those APs to downstream synapses and converting them into patterns of neurotransmitter vesicle release. This process is mediated by a rich assortment of voltage-gated ion channels whose function can be affected on…
Mickael Zbili, Dominique Debanne
Action potentials (APs) are generally produced in response to complex summation of excitatory and inhibitory synaptic inputs. While it is usually considered as a digital event, both the amplitude and width of the AP are significantly impacted by the context of its emission. In particular, the analog variations in…
Maurizio De Pittà, Nicolas Brunel
Glutamatergic gliotransmission, that is the release of glutamate from perisynaptic astrocyte processes in an activity-dependent manner, has emerged as a potentially crucial signaling pathway for regulation of synaptic plasticity, yet its modes of expression and function in vivo remain unclear. Here, we focus on two…
Vladislav Volman, Herbert Levine, Terrence J. Sejnowski, Lyle J. Graham
'Lyle J. Graham'] The sensitivity of a neuron to its input can be modulated in several ways. Changes in the slope of the neuronal input-output curve depend on factors such as shunting inhibition, background noise, frequency-dependent synaptic excitation, and balanced excitation and inhibition. However, in early…
Christian Rössert, Sergio Solinas, Egidio D'Angelo, Paul Dean + 1 more
'John Porrill'] A crucial assumption of many high-level system models of the cerebellum is that information in the granular layer is encoded in a linear manner. However, granule cells are known for their non-linear and resonant synaptic and intrinsic properties that could potentially impede linear signal transmission.…
Sooyun Kim, Arnaud J. Ruiz
Oriens-lacunosum moleculare (O-LM) interneurons in the CA1 region of the hippocampus play a key role in feedback inhibition and in the control of network activity. However, how these cells are efficiently activated in the network remains unclear. To address this question, I performed recordings from CA1 pyramidal…
Sarah Jarvis, Konstantin Nikolic, Simon Schultz
The mechanisms by which the gain of the neuronal input-output function may be modulated have been the subject of much investigation. However, little is known of the role of dendrites in neuronal gain control. New optogenetic experimental paradigms based on spatial profiles or patterns of light stimulation offer the…
William Winlow, Andrew S. Johnson
> "The great sins of the world take place in the brain, but it is in the brain that everything takes place.... it is in the brain that the poppy is red, that the apple is odorous, that the skylark sings" (Wilde, 1891 105) and the soliton and the action potential are the primary elements underlying sentience 5 – they…
Wei-Mien M. Hsu, David B. Kastner, Stephen A. Baccus, Tatyana O. Sharpee
Modulation of neuronal thresholds is ubiquitous in the brain. Phenomena such as figure-ground segmentation, motion detection, stimulus anticipation and shifts in attention all involve changes in a neuron’s threshold based on signals from larger scales than its primary inputs. However, this modulation reduces the…
Brian J Lane, Daniel R Kick, David K Wilson, Satish S Nair + 1 more
The Large Cell (LC) motor neurons of the crab (C. borealis) cardiac ganglion have variable membrane conductance magnitudes even within the same individual, yet produce identical synchronized activity in the intact network. In our previous study (35) we blocked a subset of K^+^ conductances across LCs, resulting in loss…
Ferran Galán, Stuart N. Baker
Spinal interneurons are partially phase-locked to physiological tremor around 10Hz. The phase of spinal activity is approximately opposite to descending drive to motoneurons, leading to partial phase cancellation and tremor reduction. Pre-synaptic inhibition of afferent feedback has been demonstrated to increase during…
Valentina Baruzzi, Matteo Lodi, Marco Storace, Andrey Shilnikov
How can we develop simple yet realistic models of the small neural circuits known as central pattern generators (CPGs), which contribute to generate complex multi-phase locomotion in living animals? In this paper we introduce a new model (with design criteria) of a generalized half-center oscillator (gHCO), (pools of)…
Wulfram Gerstner, Marco P. Lehmann, Vasiliki Liakoni, Dane Corneil + 1 more
'Johanni Brea'] Most elementary behaviors such as moving the arm to grasp an object or walking into the next room to explore a museum evolve on the time scale of seconds; in contrast, neuronal action potentials occur on the time scale of a few milliseconds. Learning rules of the brain must therefore bridge the gap…
Qixin Yang, Shulamit Baror-Sebban, Rotem Kipper, Michael London + 1 more
Understanding how neuronal integration is modulated by behavior is a fundamental goal in neuroscience. We combined voltage imaging with optogenetic depolarization to reveal how changes in excitatory (E) and inhibitory (I) inputs, modulate the spiking output, subthreshold dynamics, and gain of key genetically defined…
Lianchun Yu, Longfei Wang, Fei Jia, Duojie Jia
Neural oscillations are universal phenomena and can be observed at different levels of neural systems, from single neuron to macroscopic brain. The frequency of those oscillations are related to the brain functions. However, little is know about how the oscillating frequency of neural system affects neural information…
Authors not listed
Researching the EEEV virus is challenging due to the virus's high lethality and significant risk. This study employed bioinformatics methods for domain search to investigate the pathogenesis and infection process of the EEEV virus P protein. The results demonstrated that the EEEV virus P protein contains domains that…
Yuanmo Wang, Ajay Pradhan, Pankaj Gupta, Jörg Hanrieder + 2 more
Acetylcholine (ACh) is a critical neurotransmitter influencing various neurophysiological functions. Despite its significance, there is a lack of quantitative methods with adequate spatiotemporal resolution for recording single exocytotic efflux of ACh. In this study, we present an ultrafast amperometric ACh biosensor…
Authors not listed
The GluK1 receptor, an ionotropic glutamate receptor, operates as a ligand-gated ion channel. Opioids stand as the most potent pain-relieving medications currently prescribed in the medical field. Inhibiting this receptor is anticipated to result in a reduction of dopamine release in the Nucleus Accumbens, effectively…
Authors not listed
Acetylcholine (ACh) is a key neurotransmitter involved in cognitive function, motor control, and synaptic modulation, yet its electrochemical inactivity and the rapid kinetics of exocytosis have hindered real-time quantal detection. Previous micrometer-scale enzymatic ACh biosensors enabled sub-millisecond…
Afsaneh Taheri Kal-Koshvandi
We present the first light-free, genetically minimal platform for spatiotemporally resolved proximity labeling across five neuronal compartments—synaptic, nuclear, endosomal, mitochondrial, and activity-dependent microdomains. A covalent "catalyst–luciferase sandwich" architecture site-specifically conjugates five…
Guillaume Drion, Alessio Franci, Vincent Seutin, Rodolphe Sepulchre
Neuronal spiking exhibits an exquisite combination of modulation and robustness properties, rarely matched in artificial systems. We exploit the particular interconnection structure of conductance based models to investigate this remarkable property. We find that much of neuronal modulation and robustness can be…
Christoph Haag, Julia Erl, Korbinian Helbig, Joachim Wegener + 1 more
Cyclic adenosine monophosphate (cAMP) is one of the most prominent molecules involved in intracellular signaling. As a second messenger, it regulates a plethora of biochemical processes that are essential to keep a cell alive and orchestrates physiological responses to external stimuli. Ever since its discovery, great…
Jiwon Lee
Dopamine is a hormone that is released by the adrenal gland and influences motor control and motivation. Dopamine is known to have 5 receptors which are D1, D2, D3, D4 and D5, which are further categorized into 2 families: D1 family and D2 family. The D1 family is known to play a role in motivation and motor control…