24 papers · ranked by Valyu relevance
Pedro Mateos-Aparicio, Antonio Rodríguez-Moreno
Neural plasticity, also known as neuroplasticity or brain plasticity, can be defined as the ability of the nervous system to change its activity in response to intrinsic or extrinsic stimuli by reorganizing its structure, functions, or connections. A fundamental property of neurons is their ability to modify the…
Maurizio De Pittà, Nicolas Brunel, Andrea Volterra
Synaptic!plasticity!is!the!capacity!of!a!preexisting!connection!between!two! neurons! to!change!in!strength!as!a! function!of!neural!activity.!Because!synaptic! plasticity is! the! major! candidate! mechanism! for learning! and! memory,! the! elucidation! of! its! constituting! mechanisms! is! of! crucial! importance!…
Kexuan Zhang, Panlin Liao, Jin Wen, Zhonghua Hu
Schizophrenia is a severe neuropsychiatric syndrome with psychotic behavioral abnormalities and marked cognitive deficits. It is widely accepted that genetic and environmental factors contribute to the onset of schizophrenia. However, the etiology and pathology of the disease remain largely unexplored. Recently, the…
Gabby Rudenko
Synapses play a critical role in establishing and maintaining neural circuits, permitting targeted information transfer throughout the brain. A large portfolio of synaptic adhesion/organizing molecules (SAMs) exists in the mammalian brain involved in synapse development and maintenance. SAMs bind protein partners…
Kexuan Zhang, Panlin Liao, Jin Wen, Zhonghua Hu
Schizophrenia is a severe neuropsychiatric syndrome with psychotic behavioral abnormalities and marked cognitive deficits. It is widely accepted that genetic and environmental factors contribute to the onset of schizophrenia. However, the etiology and pathology of the disease remain largely unexplored. Recently, the…
Masoumeh Kourosh-Arami, Alireza Komaki, Masoumeh Gholami, Seyed Hossein Marashi + 1 more
'Seyed Hossein Marashi' 'Sara Hejazi'] Plasticity is a common feature of synapses that is stated in different ways and occurs through several mechanisms. The regular action of the brain needs to be balanced in several neuronal and synaptic features, one of which is synaptic plasticity. The different homeostatic…
Aaron D. Milstein, Yiding Li, Katie C. Bittner, Christine Grienberger + 3 more
Learning requires neural adaptations thought to be mediated by activity-dependent synaptic plasticity. A relatively non-standard form of synaptic plasticity driven by dendritic plateau potentials has been reported to underlie place field formation in hippocampal CA1 neurons. Here we found that this behavioral timescale…
Ewandson L. Lameu, Elbert E. N. Macau, Fernando S. Borges, Kelly C. Iarosz + 5 more
'Kelly C. Iarosz' 'Iberê L. Caldas' 'Rafael R. Borges' 'Paulo R. Protachevicz' 'Ricardo L. Viana' 'Antônio M. Batista'] Brain plasticity refers to brain's ability to change neuronal connections, as a result of environmental stimuli, new experiences, or damage. In this work, we study the effects of the synaptic delay on…
Kim Dore, Yvonne Pao, Jose Soria Lopez, Sage Aronson + 6 more
Which neural circuits undergo synaptic changes when an animal learns? Although it is widely accepted that changes in synaptic strength underline many forms of learning and memory, it remains challenging to connect changes in synaptic strength at specific neural pathways to specific behaviors and mem ories. Here we…
András Ecker, Daniela Egas Santander, Marwan Abdellah, Jorge Blanco Alonso + 8 more
Synaptic plasticity underlies the brain’s ability to learn and adapt. This process is often studied in small groups of neurons in vitro or indirectly through its effects on behavior in vivo. Due to the limitations of available experimental techniques, investigating synaptic plasticity at the micro-circuit level relies…
Nikos Malakasis, Spyridon Chavlis, Panayiota Poirazi
While artificial machine learning systems achieve superhuman performance in specific tasks such as language processing, image and video recognition, they do so use extremely large datasets and huge amounts of power. On the other hand, the brain remains superior in several cognitively challenging tasks while operating…
Masoumeh Kourosh-Arami, Nasrin Hosseini, Alireza Komaki
Neuroplasticity is referred to the ability of the nervous system to change its structure or functions as a result of former stimuli. It is a plausible mechanism underlying a dynamic brain through adaptation processes of neural structure and activity patterns. Nevertheless, it is still unclear how the plastic neural…
Lyes Khacef, P. Klein, Matteo Cartiglia, Arianna Rubino + 2 more
'Giacomo Indiveri' 'Elisabetta Chicca'] Abstract. Understanding how biological neural networks carry out learning using spike-based local plasticity mechanisms can lead to the development of powerful, energy-efficient, and adaptive neuromorphic processing systems. A large number of spike-based learning models have…
Wulfram Gerstner, Marco P. Lehmann, Vasiliki Liakoni, Dane Corneil + 1 more
'Johanni Brea'] Most elementary behaviors such as moving the arm to grasp an object or walking into the next room to explore a museum evolve on the time scale of seconds; in contrast, neuronal action potentials occur on the time scale of a few milliseconds. Learning rules of the brain must therefore bridge the gap…
Eddy Kwessi
Synaptic plasticity or the ability of a brain to changes one or more of its functions or structures has generated and is sill generating a lot of interest from the scientific community especially neuroscientists. These interests especially went into high gear after empirical evidences were collected that challenged the…
Mason Inman
Animals' neurons, and the synapses that connect them, are constantly changing. This plasticity is thought to underlie learning and memory. Take the rat in the maze. As he learns to navigate a new environment, familiarity with the space is reflected in the neuronal activity of a small almond-shaped brain structure…
Mayte Bonilla-Quintana, Padmini Rangamani
Effective treatments that prevent or reduce drug relapse vulnerability should be developed to relieve the high burden of drug addiction to society. This will only be possible by enhancing the understanding of the molecular mechanisms underlying the neurobiology of addiction. Recent experimental data have shown that…
Patrick Christian Trettenbrein
Synaptic plasticity is widely considered to be the neurobiological basis of learning and memory by neuroscientists and researchers in adjacent fields, though diverging opinions are increasingly being recognised. From the perspective of what we might call “classical cognitive science” it has always been understood that…
Rafael R. Borges, Fernando S. Borges, Ewandson L. Lameu, Antônio M. Batista + 4 more
'Antônio M. Batista' 'Kelly C. Iarosz' 'Iberê L. Caldas' 'Chris G. Antonopoulos' 'Maurı́cio S. Baptista'] We study the capacity of Hodgkin-Huxley neuron in a network to change temporarily or permanently their connections and behavior, the so called spike timing-dependent plasticity (STDP), as a function of their…
Samuel J. Gershman
The most widely accepted view of memory in the brain holds that synapses are the storage sites of memory, and that memories are formed through associative modification of synapses. This view has been challenged on conceptual and empirical grounds. As an alternative, it has been proposed that molecules within the cell…
Yuanmo Wang, Ajay Pradhan, Pankaj Gupta, Jörg Hanrieder + 2 more
Acetylcholine (ACh) is a critical neurotransmitter influencing various neurophysiological functions. Despite its significance, there is a lack of quantitative methods with adequate spatiotemporal resolution for recording single exocytotic efflux of ACh. In this study, we present an ultrafast amperometric ACh biosensor…
Afsaneh Taheri Kal-Koshvandi
We present the first light-free, genetically minimal platform for spatiotemporally resolved proximity labeling across five neuronal compartments—synaptic, nuclear, endosomal, mitochondrial, and activity-dependent microdomains. A covalent "catalyst–luciferase sandwich" architecture site-specifically conjugates five…
Authors not listed
Researching the EEEV virus is challenging due to the virus's high lethality and significant risk. This study employed bioinformatics methods for domain search to investigate the pathogenesis and infection process of the EEEV virus P protein. The results demonstrated that the EEEV virus P protein contains domains that…
Authors not listed
Acetylcholine (ACh) is a key neurotransmitter involved in cognitive function, motor control, and synaptic modulation, yet its electrochemical inactivity and the rapid kinetics of exocytosis have hindered real-time quantal detection. Previous micrometer-scale enzymatic ACh biosensors enabled sub-millisecond…