23 papers · ranked by Valyu relevance
Elise Cachat, Weijia Liu, Peter Hohenstein, Jamie A Davies
Background In mammalian development, the formation of most tissues is achieved by a relatively small repertoire of basic morphogenetic events (e.g. cell adhesion, locomotion, apoptosis, etc.), permutated in various sequences to form different tissues. Together with cell differentiation, these mechanisms allow…
Salma Zahran, Zhou Ao, Zhengyang Zhang, Chen Chi + 2 more
Semantic segmentation of microscopy images is a critical task for high-throughput materials characterisation, yet its automation is severely constrained by the prohibitive cost, subjectivity, and scarcity of expert-annotated data. While physicsbased simulations offer a scalable alternative to manual labelling, models…
Konstantin Gavriljuk, Bruno Scocozza, Farid Ghasemalizadeh, Akhilesh P. Nandan + 5 more
Cytoskeletal dynamics regulated by extracellular signaling provides the morphogenic plasticity of eukaryotic cells. To uncover fundamental principles of cell morphogenesis, we reconstituted an out-of-equilibrium Synthetic Morphogenic Membrane System (SynMMS) consisting of a dynamic microtubule (MT)-aster together with…
Sehyun Chun, Sidhartha Roy, Yen T. Nguyen, Joseph B. Choi + 2 more
'H. S. Udaykumar' 'Stephen S. Baek'] The sensitivity of heterogeneous energetic (HE) materials (propellants, explosives, and pyrotechnics) is critically dependent on their microstructure. Initiation of chemical reactions occurs at hot spots due to energy localization at sites of porosities and other defects. Emerging…
Anton S. Zadorin, Yannick Rondelez, Guillaume Gines, Vadim Dilhas + 4 more
'Georg Urtel' 'Adrian Zambrano' 'Jean-Christophe Galas' 'André Estevez‐Torres'] 1Universite Pierre et Marie Curie, Laboratoire Jean Perrin, 4 place Jussieu, 75005 Paris, France. ´ 2CNRS, UMR 8237, 75005, Paris, France. 3LIMMS/CNRS-IIS, University of Tokyo, Komaba 4-6-2 Meguro-ku, Tokyo, Japan. 4Ecole superieure de…
Jasmine Nguyen-Duc, Malte Brammerloh, Melina Cherchali, Inès de Riedmatten + 3 more
Monte Carlo diffusion simulations in numerical substrates are valuable for exploring the sensitivity and specificity of the diffusion MRI (dMRI) signal to realistic cell microstructure features. A crucial component of such simulations is the use of numerical phantoms that accurately represent the target tissue, which…
Yadian Xie, Duygu Kocaefe, Yasar Kocaefe, Johnathan Cheng + 1 more
Alumina is an inorganic material, which is widely used in ceramics, catalysts, catalyst supports, ion exchange and other fields. The micromorphology of alumina determines its application in high tech and value-added industry and its development prospects. This paper gives an overview of the liquid phase synthetic…
Atikur Rahman, Pawel W. Majewski, Gregory Doerk, Charles T. Black + 1 more
'Kevin G. Yager'] Self-assembly is a powerful paradigm, wherein molecules spontaneously form ordered phases exhibiting well-defined nanoscale periodicity and shapes. However, the inherent energy-minimization aspect of self-assembly yields a very limited set of morphologies, such as lamellae or hexagonally packed…
Zhengyang Guo, Kaiming Xu, Zi Wang, Jingyi Ke + 3 more
Accurate segmentation of subcellular components is crucial for understanding cellular processes, but traditional methods struggle with noise and complex structures. Convolutional neural networks improve accuracy but require large, time-consuming, and biased manually annotated datasets. Here, we developed SynSeg, a…
Authors not listed
Polyacrylonitrile flower-like particles (PANFs), as hierarchical superstructures, have recently found applications in catalysis, batteries, sensing, and gas absorption. Yet, precise control over their size and morphology which dictate their properties remains challenging, as the role of reaction parameters in their…
Joseph, Merin, Read, Daniel J. + 2 more
We present a novel computational implementation of strong segregation theory, developed specifically for calculations of phase separated ABC star terpolymers. The method allows calculation of free energies of common two-dimensional morphologies for these polymers and the efficient construction of phase diagrams. The…
Hugo E. L. Martay
There are a number of ways to procedurally generate interesting three-dimensional shapes, and a method where a cellular neural network is combined with a mesh growth algorithm is presented here. The aim is to create a shape from a genetic code in such a way that a crude search can find interesting shapes.
Juan A Allegretto, Diego Onna, Laura Acion, Sara A Bilmes + 2 more
Metal-Organic Frameworks (MOFs) have settled in the scientific community over the last decades as versatile materials with several applications. Among those, Zeolitic Imidazolate Framework 8 (ZIF-8) is a well-known MOF that has been applied in various and diverse fields, from drug-delivery platforms to…
Yuval Elani
The quest to construct artificial cells from the bottom-up using simple building blocks has received much attention over recent decades and is one of the grand challenges in synthetic biology. Cell mimics that are encapsulated by lipid membranes are a particularly powerful class of artificial cells due to their…
Stephanie A. Nick McElhinny, Jennifer J. Becker
The U.S. Army Research Office (ARO) serves as the Army's premier extramural basic research agency in the engineering, physical, information and life sciences. ARO drives the national basic research agenda and programs in these areas to create new scientific discoveries and increase knowledge through high-risk…
Suleiman Mousa, Sean P. Rigby, Lucjan Chmielarz
This review considers the use of fractal concepts to improve the development, fabrication, and characterisation of catalytic materials and supports. First, the theory of fractals is discussed, as well as how it can be used to better describe often highly complex catalytic materials and enhance structural…
Janice L. Pappas
Morphological surface features are a record of genetic and developmental processes as well as environmental influences. The 3D geometric “terrain” of the surface consists of slopes via tangents, peaks and valleys via normals, smoothness of the transition between peaks and valleys, and point connections as flatness or…
Rahul Upadhya, Matthew Tamasi, Elena Di Mare, Sanjeeva Murthy + 1 more
The functional structure of proteins is heavily influenced by their folding behavior. AlphaFold, a powerful artificial intelligence (AI) program trained on information from the Protein Data Bank (PDB), was developed to predict the 3D structure of proteins from its amino acid sequence. Inspired by this, we aim to…
Authors not listed
Synthetic cells emulate fundamental biological behaviors, such as growth, metabolism, and evolution, under non-equilibrium conditions, but have lacked genotype-driven selection, which is essential for Darwinian evolution. Here, we introduce short DNA sequences as genotypes into fuel-dependent, peptide-RNA-based…
Søren Leth Mejlsøe, Johannes Fabritius Petersen, Jørn Bolstad Christensen
In this paper, we present for the first time a general scalable, synthetic scheme that allows control over the position and number of different surface groups on PAMAM-dendrimers. The methodology is based on synthesis of small AB2-building blocks and cores having orthogonal protective groups allowing synthesis of…
Andrea Veciana, Gemma Llauradó-Capdevila, Alvaro Mayoral, Ramon Pons + 14 more
Covalent organic frameworks (COFs) are crystalline materials with intrinsic porosity that offer a wide range of potential applications spanning diverse fields. Yet, the main goal in the COF research area is to achieve the most stable thermodynamic product while simultaneously targeting the desired size and structure…
Søren Leth Mejlsøe, Johannes Fabritius Petersen, Jørn Bolstad Christensen
Dendrimers are synthetic macromolecules with a tree-like structure based on repetitive branching from a core. This type of growth leads to macromolecules rapidly increasing in size and molecular weight making them well-defined, covalently bound nanoparticles. Dendrimers are also an example of a class of compounds…
Stef A. H. Jansen, Ghislaine Vantomme, E. W. Meijer
Inspired by the dynamic assembly of fibrillar proteins in biology, research on supramolecular polymers has progressed rapidly toward the development of synthetic multicomponent systems. In this review, we highlight recent advances in the study of supramolecular polymers in solution, with an emphasis on how combined…