16 papers · ranked by Valyu relevance
Carmen Rodriguez-Cerdeira, Elena Sanchez-Blanco, Alberto Molares-Vila
Background. Inflammation-driven immune dysfunction supports the development of several chronic human disorders including skin diseases. Nonantibiotic macrolides have anti-inflammatory and/or immunomodulatory activity that suggests the exploitation of these in the treatment of skin diseases characterized by inflammatory…
Alexander Muacevic, John R Adler, Ripudaman S Munjal, Jagdish Sharma + 6 more
'Srinija Polishetti' 'Pushkar Sai Valleru' 'Himanshi Banker' 'Ramansh Bandhu Gupta' 'FNU Anamika' 'Rohit Jain'] Tacrolimus, widely known as Prograf, has become the preferred immunosuppressant for preventing graft rejection in solid organ transplant recipients, particularly in steroid-sparing regimens. Its efficacy and…
Alexander Muacevic, John R Adler, Badar Uddin Umar, Sayeeda Rahman + 6 more
'Siddhartha Dutta' 'Tariqul Islam' 'Nadia Nusrat' 'Kona Chowdhury' 'Wan Farizatul Shima Binti Wan Ahmad Fakuradzi' 'Mainul Haque'] Atopic dermatitis (AD) is a long-lasting inflammatory dermatological condition characterized by itchy, eczematous, sparsely tiny blisters that hold a clear watery substance. Additionally…
Anders Larsson, Johan Saldeen, Jonathan Cedernaes, Mats B. Eriksson + 3 more
Background: Tacrolimus is a key immunosuppressive drug used to prevent organ rejection after transplantation. Its narrow therapeutic window and high interindividual pharmacokinetic variability make therapeutic drug monitoring (TDM) essential. This study aimed to (1) characterize long-term trends in tacrolimus…
Lalitendu Mohanty, Sumit Bhushan, Bernd Rüttger
Objective: The present study compared the pharmacokinetics of two (1 mg) tacrolimus formulations (test (generic from Panacea) and reference (innovator from Astellas)) after a single-dose administration as per the European Medicine Agency (EMA) guidelines to grant marketing authorization. Materials and methods: This…
Marion Barrieu, Philip Chennell, Mouloud Yessaad, Yassine Bouattour + 6 more
Tacrolimus is an immunosuppressant used to treat a large variety of inflammatory or immunity-mediated ophthalmic diseases. However, there are currently no commercial industrial forms available that can provide relief to patients. Various ophthalmic formulations have been reported in the literature, but their stability…
Hassan Aouad, Quentin Faucher, François-Ludovic Sauvage, Emilie Pinault + 4 more
Tacrolimus, an immunosuppressive drug prescribed to a majority of transplanted patients is nephrotoxic, through still unclear mechanisms. This study aims to evaluate the impact of tacrolimus on a lineage of proximal tubular cells using a multi-omics approach. LLC-PK1 cells were exposed to 5 M of tacrolimus for 24h.…
Yukuang Guo, Camila Manoel Crnkovic, Kyoung-Jae Won, Xiaotong Yang + 4 more
Tacrolimus exhibits low and variable drug exposure after oral dosing, but the contributing factors remain unclear. We recently reported a positive correlation between fecal abundance of Faecalibacterium prausnitzii and oral tacrolimus dose in kidney transplant patients. To determine whether F. prausnitzii and other gut…
Simeon C. Daeschler, Katelyn Chan, Konstantin Feinberg, Marina Manoraj + 6 more
Axonal regeneration following nerve repair is slow and often incomplete, resulting in poor functional recovery and sometimes lifelong disability. Yet, there are no FDA-approved therapies available to promote nerve regeneration. Tacrolimus accelerates axonal regeneration, but systemic side-effects presently outweigh its…
Xiaojun Cai, Wang Zheng-xin, Li Ruidong, Yifeng Tao + 7 more
'Zhang Xiaofei' 'Juan Li' 'Conghuan Shen' 'Xiaoyan Qiu' 'Jianhua Li' 'Zheng Jiao'] Diverse tacrolimus population pharmacokinetic (popPK) models in adult liver transplant recipients have been established to describe the PK characteristics of tacrolimus in the last two decades. However, their extrapolated predictive…
Xiaojun Cai, Huizhu Song, Zheng Jiao, Hang Yang + 6 more
'Chengyu Wang' 'Dong Wei' 'Lingzhi Shi' 'Bo Wu' 'Jinyu Chen'] We aimed to (i) develop a population pharmacokinetic model of tacrolimus in Chinese lung transplant recipients, and (ii) propose model-based dosing regimens for individualized treatment. We obtained 807 tacrolimus steady-state whole blood concentrations from…
Andrea M. Storås, Anders Åsberg, Pål Halvorsen, Michael A. Riegler + 1 more
'Inga Strümke'] Abstract—Tacrolimus is one of the cornerstone immunosuppressive drugs in most transplantation centers worldwide following solid organ transplantation. Therapeutic drug monitoring of tacrolimus is necessary in order to avoid rejection of the transplanted organ or severe side effects. However, finding the…
Ghazaleh Zarrinrad, Lisa-Marie Burkhardt, Dimitrios Laurin Wagner, Stephan Schlickeiser + 40 more
Background: Unwanted immune responses play a central role in the pathogenesis of solid organ allograft rejection. These are managed by life-long immunosuppression with considerable burden for the patient and society. Adoptive therapy with regulatory T-cells (Treg) is a promising approach to restore sustainable immune…
Yuhui Chai, Lili Hu, Quan Du, Yunyun Yang + 1 more
intra-individual variability in recipients of heart transplants during the early post-heart transplantation period Authors: ['Yuhui Chai' 'Lili Hu' 'Quan Du' 'Yunyun Yang' 'Zhuo Wang'] This study aimed to investigate the effects of genetic polymorphisms on tacrolimus blood levels and intra-individual variability in…
Lingfei Huang, Yixi Liu, Zheng Jiao, Junyan Wang + 2 more
'Jianhua Mao'] Data were obtained from 71 pediatric patients with PNS, along with 525 TAC trough concentrations at steady state. The demographic, medical, and treatment details were collected. Genetic polymorphisms of CYP3A41G, CYP3A53, and ABCB1-C3435T were analyzed. The PPK models were developed using nonlinear…
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The rise of fungal infections has become a pressing global health concern, affecting millions and leading to significant mortality, particularly among immunocompromised individuals. While antifungal treatments have played a crucial role in managing these infections, the increasing prevalence of resistant strains…