28 papers · ranked by Valyu relevance
Priyanka Rawat, Ujala Sehar, Jasbir Bisht, Ashley Selman + 3 more
'John Culberson' 'P. Hemachandra Reddy' 'Stefanie Kürten'] Alzheimer’s disease (AD) is the leading cause of dementia in elderly people. Amyloid beta (Aβ) deposits and neurofibrillary tangles are the major pathological features in an Alzheimer’s brain. These proteins are highly expressed in nerve cells and found in most…
She, Xutong
Alzheimer's disease (AD) persists as a paramount challenge in neurological research, characterized by the pathological hallmarks of amyloid-β (Aβ) plaques and neurofibrillary tangles composed of hyperphosphorylated tau. This review synthesizes the evolving understanding of AD pathogenesis, moving beyond the linear…
Xingyu Zhang, Jiangyu Wang, Zhentao Zhang, Keqiang Ye
The deposition of abnormal tau protein is characteristic of Alzheimer’s disease (AD) and a class of neurodegenerative diseases called tauopathies. Physiologically, tau maintains an intrinsically disordered structure and plays diverse roles in neurons. Pathologically, tau undergoes abnormal post-translational…
Miguel Medina, Jesús Avila
The microtubule-associated protein (MAP) tau plays a critical role in the pathogenesis of Alzheimer’s disease (AD) and several related disorders collectively known as tauopathies. Development of tau pathology is associated with progressive neuronal loss and cognitive decline. In the brains of AD patients, tau pathology…
Dah-eun Chloe Chung, Shanu Roemer, Leonard Petrucelli, Dennis W. Dickson
'Dennis W. Dickson'] Microtubule-associated protein tau is abnormally aggregated in neuronal and glial cells in a range of neurodegenerative diseases that are collectively referred to as tauopathies. Multiple studies have suggested that pathological tau species may act as a seed that promotes aggregation of endogenous…
Dmytro Morderer, Melissa C. Wren, Feilin Liu, Naomi Kouri + 8 more
Tauopathies represent a diverse group of neurodegenerative disorders characterized by the abnormal aggregation of the microtubule-associated protein tau. Despite extensive research, the precise mechanisms underlying the complexity of different types of tau pathology remain incompletely understood. Here we describe an…
Niyatee Samudra, Courtney Lane-Donovan, Lawren VandeVrede, Adam L. Boxer
'Adam L. Boxer'] Tauopathies are disorders associated with tau protein dysfunction and insoluble tau accumulation in the brain at autopsy. Multiple lines of evidence from human disease, as well as nonclinical translational models, suggest that tau has a central pathologic role in these disorders, historically thought…
Dorothea Böken, Melissa Huang, Yunzhao Wu, Emre Fertan + 9 more
Tauopathies are neurodegenerative diseases marked by pathological tau aggregation. While disease-specific folds of insoluble tau filaments have been established, it remains unclear whether the smaller, earlier species also differ across tauopathies. Here, we characterise these small tau aggregates from post-mortem…
Jaime Vaquer-Alicea, Marc I. Diamond, Lukasz A. Joachimiak
Tauopathies consist of over 25 different neurodegenerative diseases that include argyrophilic grain disease (AGD), progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), and Pick’s disease (PiD). Tauopathies are defined by brain accumulation of microtubule-associated protein tau in fibrillar aggregates…
Felix Langerscheidt, Tamara Wied, Mohamed Aghyad Al Kabbani, Thilo van Eimeren + 2 more
'Thilo van Eimeren' 'Gilbert Wunderlich' 'Hans Zempel'] Tauopathies are a heterogeneous group of neurologic diseases characterized by pathological axodendritic distribution, ectopic expression, and/or phosphorylation and aggregation of the microtubule-associated protein TAU, encoded by the gene MAPT. Neuronal…
She Xutong
Alzheimer's disease (AD) stands as the predominant form of dementia, presenting significant and escalating global challenges. It is characterized by various pathological markers in the brain——large numbers ofamyloid plaques surrounded by neurons containing neurofibrillary tangles, vascular damage from extensive plaque…
Parisa Tabeshmehr, Eftekhar Eftekharpour, Chiara Villa
Simple Summary Tau is an important protein for maintaining the shape and normal function of nerve cells. There are many diseases that are identified by changes in this protein, yet examination of tau in these diseases shows robust differences in tau modifications. A question arises from these observations on whether…
Chen Lyu, Stefano Da Vela, Youssra Al-Hilaly, Karen E. Marshall + 5 more
Tau35 is a truncated form of tau found in human brain in a subset of tauopathies. Tau35 expression in mice recapitulates key features of human disease, including progressive increase in tau phosphorylation, along with cognitive and motor dysfunction. The appearance of aggregated tau suggests that Tau35 may have…
Jeanne Espourteille, Aatmika Barve, Valentin Zufferey, Elodie Leroux + 8 more
Tauopathies are neurodegenerative disorders characterized by abnormal tau aggregation, with primary 3R (e.g., Pick’s disease, PiD) and 4R (e.g., progressive supranuclear palsy, PSP) variants posing a significant diagnostic challenge. Here, we examined brain-derived extracellular vesicles (BD-EVs) isolated from the…
Dina W. Yakout, Ankit Shroff, Vishrut Thaker, Zachary D. Allen + 2 more
Tauopathies are neurodegenerative disorders characterized by the deposition of aggregates of the microtubule associated protein tau, a main component of neurofibrillary tangles. Alzheimer’s disease (AD) is the most common type of tauopathy and dementia, with amyloid-beta pathology as an additional hallmark feature of…
Hamad Yadikar, Isabel Torres, Gabrielle Aiello, Milin Kurup + 5 more
Tauopathies are a class of neurodegenerative disorders characterized by abnormal deposition of post-translationally modified tau protein in the human brain. Tauopathies are associated with Alzheimer’s disease (AD), chronic traumatic encephalopathy (CTE), and other diseases. Hyperphosphorylation increases tau tendency…
Zerui Wang, Ling Wu, Maria Gerasimenko, Tricia Gilliland + 6 more
Tauopathies are a group of age-related neurodegenerative diseases with a molecular hallmark of the prion-like propagation and accumulation of pathologically phosphorylated tau protein in the brain. They include Alzheimer’s disease (AD), progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), and Pick’s…
Megan A. Iida, Kurt Farrell, Jamie M. Walker, Timothy E. Richardson + 21 more
Primary age-related tauopathy (PART) is a form of Alzheimer-type neurofibrillary degeneration occurring in the absence of amyloid-beta (Aβ) plaques. While PART shares some features with Alzheimer disease (AD), such as progressive accumulation of neurofibrillary tangle pathology in the medial temporal lobe and other…
Irina Kareva
Alzheimer's disease is not the outcome of a single cause but the convergence of many. This review reframes dementia as a systemic failure, where amyloid plaques and tau tangles are not root causes but late-stage byproducts of the underlying metabolic collapse. We begin by tracing the historical merger of early- and…
Wyatt Powell, Ruiheng Jing, Maciej Walczak
Deposits of the microtubule-associated protein tau (MAPT) serve as a hallmark of neurodegenerative diseases known as tauopathies. Numerous studies have demonstrated that in diseases such as Alzheimer’s disease (AD), tau undergoes extensive remodeling. The attachment of post-translational modifications distributed…
Authors not listed
Tau protein aggregation is a hallmark of Alzheimer’s disease, and disrupting this process presents a compelling therapeutic strategy. In this scaffold-focused pilot study, we present an AI-driven cheminformatics workflow to evaluate a curated library of 16 novel triazole–naphthalene derivatives (TNDs) designed for…
Authors not listed
Alzheimer’s disease (AD) is a complex and progressive neurodegenerative disorder characterized by memory loss, cognitive decline, and neuronal death. A defining pathological hallmark of AD is the formation of intracellular neurofibrillary tangles composed of hyperphosphorylated tau protein. Inhibiting the aggregation…
Jingwen Zhang, Defu Yang, Wei He, Guorong Wu + 1 more
Currently, many studies of Alzheimer's disease (AD) are investigating the neurobiological factors behind the acquisition of beta-amyloid (A), pathologic tau (T), and neurodegeneration ([N]) biomarkers from neuroimages. However, a system-level mechanism of how these neuropathological burdens promote neurodegeneration…
Rumiana Tenchov, Janet Sasso, Qiongqiong Angela Zhou
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, memory loss, and impaired daily functioning. The pathology of AD is marked by the accumulation of amyloid-beta plaques and tau protein tangles in brain, along with neuroinflammation and synaptic dysfunction. Genetic…
Pulkit Khandelwal, Michael Tran Duong, Shokufeh Sadaghiani, Sydney Lim + 32 more
'Sydney Lim' 'Amanda E Denning' 'Eunice Chung' 'Sadhana Ravikumar' 'Sanaz Arezoumandan' 'Claire M. Peterson' 'Madigan L. Bedard' 'Noah Capp' 'Ranjit Ittyerah' 'Elyse Migdal' 'Grace Choi' 'Emily Kopp' 'Bridget Loja' 'Eusha Hasan' 'Jiacheng Li' 'Karthik Prabhakaran' 'Gabor Mizsei' 'M. Gabrielyan' 'Theresa Schuck'…
Authors not listed
Alzheimer's disease (AD) is a neurodegenerative disorder with gradual cognitive deterioration and complex pathophysiological mechanisms include amyloid-β aggregation, tau hyperphosphorylation, cholinergic dysfunction, and altered proteostasis. Finding multi-target ligands that can simultaneously modulate several…
Wojciech Michno, Patrick Wehrli, Srinivas Koutarapu, Christian Marsching + 9 more
Understanding of Alzheimer’s disease (AD) pathophysiology, requires molecular assessment of how key pathological factors, specifically amyloid β (Aβ) plaques, influence the surrounding microenvironment. Here, neuronal lipids are particularly of interest as these are implicated in pathological- and neurodegenerative…
Yu Shen
Alzheimer's disease (AD) is a neurodegenerative disorder that affects millions of people worldwide. Early screening is crucial to prevent potential damages, and researchers are exploring alternative approaches such as multiplexed assays and emerging technologies such as microfluidics, nanotechnology, and biosensors.…