16 papers · ranked by Valyu relevance
Kyeong‐won Yeop, Hyun‐ju Nam, Chang‐jae Shim, So‐mi Yang + 4 more
Biopharmaceutical manufacturing processes in which the product of interest is extracellularly expressed typically employ a clarification step following cell culture or fermentation. During clarification, crude cell culture fluid or fermentation broth is processed to remove insoluble solids, cells, debris, and other…
James A. Sargent, Victoria HJ Roberts, Jessica Gaffney, Antonio E. Frias
Placental function is essential for the development of the fetus, and is – in part – related to the 3D arrangement of the villous and vascular geometry. Recent advances in tissue clarification techniques allow for deep high-resolution imaging with confocal microscopy without altering the spatial characteristics of the…
Eline de Jong, Sebastian De Haro
Technological understanding is not a singular concept but varies depending on the context. Building on De Jong and De Haro's (2025) notion of technological understanding as the ability to realise an aim by using a technological artefact, this paper further refines the concept as an ability that varies by context and…
Aaron Almeida, David Chau, Thomas Coolidge, Hani El‐Sabbahy + 4 more
Recent advancements in cell culture engineering have allowed drug manufacturers to achieve higher productivity by driving higher product titers through cell line engineering and high-cell densities. However, these advancements have shifted the burden to clarification and downstream processing where the difficulties now…
Hamed Zamani, Gord Lueck, Everest Chen, Rodolfo Quispe + 2 more
'Nick Craswell'] Search clarification has recently attracted much attention due to its applications in search engines. It has also been recognized as a major component in conversational information seeking systems. Despite its importance, the research community still feels the lack of a large-scale data for studying…
Chris Madge, Matthew Purver, Massimo Poesio
In this work we examine LLMs' ability to ask clarification questions in task-oriented dialogues that follow the asynchronous instructiongiver/instruction-follower format. We present a new corpus that combines two existing annotations of the Minecraft Dialogue Corpus — one for reference and ambiguity in reference, and…
Zhou Zhou, Xiaogai Li, Yuzhe Liu, Warren N. Hardy + 1 more
Traumatic brain injury (TBI) is an alarming global public health issue with high morbidity and mortality rates. Although the causal link between external insults and consequent brain injury remains largely elusive, both strain and strain rate are generally recognized as crucial factors for brain injury development.…
Matthew Di Prima, James Coburn, David Hwang, Jennifer Kelly + 2 more
'Akm Khairuzzaman' 'Laura Ricles'] Additive manufacturing/3D printing of medical devices is becoming more commonplace, a 3D printed drug is now commercially available, and bioprinting is poised to transition from laboratory to market. Despite the variety of technologies enabling these products, the US Food and Drug…
Anderson A. Butler, Jason Kras, Karolina Chwalek, Enrique I. Ramos + 3 more
DNA methylation microarrays have become a widely used tool for investigating epigenetic modifications in various aspects of biomedical research. However, technical variability in methylation data poses challenges for downstream applications such as predictive modeling of health and disease. In this study, we measure…
Authors not listed
Antioxidant tests have been applied in various tests of foods and beverages in various forms, even in nanoscale. Information on antioxidant activity is important as an indicator that handles free radicals. So far, many antioxidant tests have used DPPH reagent, commonly known as the DPPH method. By referring to SNI, its…
Authors not listed
High production costs remain a major obstacle to the commercialization of cell-based foods, primarily because of the reliance on costly pharmaceutical-grade reagents and infrastructure. This study introduces a practical solution using a dual technical and regulatory approach. We developed iCoater, a ready-to-use…
Victor M. Arias-Peregrino, Aldo Y. Tenorio-Barajas, Claudia O. Mendoza-Barrera, Jesús Román-Doval + 4 more
Organ failure constitutes a significant global concern requiring urgent attention. While organ transplantation offers prospective treatment, it remains suboptimal. The scarcity of donor organs and the need for lifelong immunosuppressive treatments highlight the necessity for innovative approaches in regenerative…
Christian G. Habeck, Adam M. Brickman
Our ability to draw conclusions from experiments often relies on the application of inferential statistics, such as those included within the general-linear-modeling framework. The purpose of this commentary is to direct attention a common fallacy that can be observed in paper reviews and professional exchanges in the…
Lingzhi Ding, Guangchao Song, Guili Gao, Dequan Shi + 1 more
Magnetorheological Finishing (MRF) technology, as a deterministic machining method featuring flexibility, controllability, and extremely low subsurface damage, has become one of the most promising technologies in the field of ultra-precision polishing. This review systematically summarizes the research progress of MRF…
Authors not listed
Climate change mitigation is driving growing innovation in bio-materials production technologies, with a focus on improving their environmental sustainability. This study presents a decision-support framework based on a careful integration of technical requirements, implemented in a process digital twin and life cycle…
Yalin Li, John Trimmer, Steven Hand, Xinyi Zhang + 6 more
The pursuit of sustainability has catalyzed broad investment in the research, development, and deployment (RD&D) of innovative water, sanitation, and resource recovery technologies, yet the lack of transparent and agile methodologies to navigate the expansive landscape of technology development pathways remains a…