25 papers · ranked by Valyu relevance
Cédric Maurange
The developing central nervous system (CNS) is particularly prone to malignant transformation, but the underlying mechanisms remain unresolved. However, periods of tumor susceptibility appear to correlate with windows of increased proliferation, which are often observed during embryonic and fetal stages and reflect…
Yen-Chung Chen, Nikolaos Konstantinides
The nervous system is one of the most sophisticated animal tissues, consisting of thousands of interconnected cell types. How the nervous system develops its diversity from a few neural stem cells remains a challenging question. Spatial and temporal patterning mechanisms provide an efficient model through which…
Andreas Sagner, Isabel Zhang, Thomas Watson, Jorge Lazaro + 2 more
The molecular mechanisms that ensure the reproducible generation of neuronal diversity in the vertebrate nervous system are incompletely understood. Here we provide evidence of a temporal patterning program consisting of cohorts of transcription factors expressed in neurons generated at successive developmental…
Jimena Garcia-Guillen, Mahla Ahmadi, Theophilus Frimpong, Iris Seaman + 6 more
How spatial patterns arise during embryonic development is classically explained by the French Flag model, in which cells acquire positional identities by interpreting morphogen concentration thresholds. However, in many developmental systems, spatial patterns instead emerge progressively through temporal programs of…
Guohua Yuan, Zhe Zhao, Xiaoxiang Dong, Xu-Wen Wang + 11 more
In the developing neocortex, a diverse array of neurons with defined types and abundances are systematically generated by a limited population of radial glial progenitors (RGPs) as they undergo successive fate changes. The molecular regulation behind this intricate temporal patterning remains elusive. We undertook…
Andreas Sagner, Isabel Zhang, Thomas Watson, Jorge Lazaro + 3 more
'Manuela Melchionda' 'James Briscoe' 'Claude Desplan'] The molecular mechanisms that produce the full array of neuronal subtypes in the vertebrate nervous system are incompletely understood. Here, we provide evidence of a global temporal patterning program comprising sets of transcription factors that stratifies…
Hailun Zhu, Sihai Dave Zhao, Alokananda Ray, Yu Zhang + 1 more
During development, neural stem cells are temporally patterned to sequentially generate a variety of neural types before exiting the cell cycle. Temporal patterning is well-studied in Drosophila, where neural stem cells called neuroblasts sequentially express cascades of Temporal Transcription Factors (TTFs) to control…
Isabel Zhang, Giulia LM Boezio, Jake Cornwall-Scoones, Thomas Frith + 6 more
The vertebrate neural tube generates a large diversity of molecularly and functionally distinct neurons and glia from a small progenitor pool. While the role of spatial patterning in organising cell fate specification has been extensively studied, temporal patterning, which controls the timing of cell type generation…
Katie H. Long, Justin D. Lieber, Sliman J. Bensmaia
Humans are exquisitely sensitive to the microstructure and material properties of surfaces. In the peripheral nerves, texture information is conveyed via two mechanisms: coarse textural features are encoded in spatial patterns of activation that reflect their spatial layout, and fine features are encoded in highly…
Andrea Lopes, Elia Magrinelli, Ludovic Telley
The complexity of brain structure and function is rooted in the precise spatial and temporal regulation of selective developmental events. During neurogenesis, both vertebrates and invertebrates generate a wide variety of specialized cell types through the expansion and specification of a restricted set of neuronal…
Emmanuelle Tognoli, Daniela Benites, J. A. Scott Kelso
— The functioning of an organ such as the brain emerges from interactions between its constituent parts. Further, this interaction is not immutable in time but rather unfolds in a succession of patterns, thereby allowing the brain to adapt to constantly changing exterior and interior milieus. This calls for a framework…
Van Long Ho, Nguyen Ho, Torben Bach Pedersen, Panagiotis Papapetrou
—Big time series are increasingly available from an ever wider range of IoT-enabled sensors deployed in various environments. Significant insights can be gained by mining temporal patterns from these time series. Temporal pattern mining (TPM) extends traditional pattern mining by adding event time intervals into…
Kono, Yohei, Tajima, Yoshiyuki
Extracting pulsive temporal patterns from a small dataset without their repetition or singularity shows significant importance in manufacturing applications but does not sufficiently attract scientific attention. We propose to quantify how long temporal patterns appear without relying on their repetition or…
Rebecca M Leech, Stephanie E Chappel, Nicola D Ridgers, Heather A Eicher-Miller + 2 more
'Heather A Eicher-Miller' 'Ralph Maddison' 'Sarah A McNaughton'] Dietary and movement behaviors [physical activity (PA), sedentary behavior (SED), and sleep] occur throughout a 24-h day and involve multiple contexts. Understanding the temporal patterning of these 24-h behaviors and their contextual determinants is key…
Joel Zirkle, Leonid L. Rubchinsky
Synchronization of neural activity in the brain is involved in multiple neural functions (e.g. Buzsáki and Draguhn, 2004; Fell and Axmacher, 2011; Fries, 2015; Harris and Gordon, 2015). Neural synchronization that is either too strong or too weak may be one of the neurophysiological factors behind symptoms of several…
Semir Zeki, Oliver J. Hulme, Barrie Roulston, Michael Atiyah + 1 more
'Ernest Greene'] In the work reported here, we set out to study the neural systems that detect predictable temporal patterns and departures from them. We used functional magnetic resonance imaging (fMRI) to locate activity in the brains of subjects when they viewed temporally regular and irregular patterns produced by…
Marcos Rodríguez Regueira, Jesús Daza García, Alfonso Rodríguez-Patón Aradas
The multicellular incoherent feedforward loop (mIFFL) is an extension of the traditional intracellular IFFL gene motif where the interacting nodes no longer need to be genes inside the same cell but can be spatially distributed in different cells. We studied for the first time the spatial computing abilities of these…
Authors not listed
Laser modification of polymer surfaces is critical in many contexts including self-cleaning materials, microelectronics, and biomedical research. Despite their utility, accessing these modified polymers requires expensive or complex materials and multi-step fabrication, masking, and washing processes. Here, we present…
Matthew Bailey, Mark Wilson
One of the critical tools of persistent homology is the persistence diagram. We demonstrate the applicability of a persistence diagram showing the existence of topological features (here rings in a 2D network) generated over time instead of space as a tool to analyse trajectories of biological networks. We show how the…
Zedong Bi, Changsong Zhou
a Institute for Future, Qingdao University, Shandong 266071, China bDepartment of Physics, Centre for Nonlinear Studies and Institute of Computational and Theoretical Studies, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China cResearch Centre, HKBU Institute of Research and Continuing Education, Shenzhen…
Tony Lindeberg
This article presents an overview of a theory for performing temporal smoothing of temporal signals in such a way that: (i) temporally smoothed signals at coarser temporal scales are guaranteed to constitute simplifications of corresponding temporally smoothed signals at any finer temporal scale (including the original…
Zafeirios Fountas, Alexey Zakharov
Enquiries concerning the underlying mechanisms and the emergent properties of a biological brain have a long history of theoretical postulates and experimental findings. Today, the scientific community tends to converge to a single interpretation of the brain's cognitive underpinnings – that it is a Bayesian inference…
Authors not listed
We report the discovery of highly ordered photoinduced patterns in two-dimensional layered copper halide perovskites under ultraviolet illumination in ultrahigh vacuum. In contrast to conventional random degradation observed in metal halide perovskites, these perovskites exhibit directional nanoscale grooves with…
Authors not listed
The capacity to pattern biomolecules within microfluidic devices expands the scope of microfluidic technologies. In such patterned systems, surface-bound components remained localized, while the microfluidic network supplies reagents and removes waste products. This approach has enabled continuous protein expression…
Authors not listed
Self-organizing tissues, such as organoids, offer transformative potential beyond healthcare by enabling the sustainable production of advanced materials. Resource scarcity and global warming drive the need for innovative fabrication solutions. This prospective review explores developmental biology as a manufacturing…