16 papers · ranked by Valyu relevance
Cédric Maurange
The developing central nervous system (CNS) is particularly prone to malignant transformation, but the underlying mechanisms remain unresolved. However, periods of tumor susceptibility appear to correlate with windows of increased proliferation, which are often observed during embryonic and fetal stages and reflect…
Andreas Sagner, Isabel Zhang, Thomas Watson, Jorge Lazaro + 3 more
'Manuela Melchionda' 'James Briscoe' 'Claude Desplan'] The molecular mechanisms that produce the full array of neuronal subtypes in the vertebrate nervous system are incompletely understood. Here, we provide evidence of a global temporal patterning program comprising sets of transcription factors that stratifies…
Yen-Chung Chen, Nikolaos Konstantinides
The nervous system is one of the most sophisticated animal tissues, consisting of thousands of interconnected cell types. How the nervous system develops its diversity from a few neural stem cells remains a challenging question. Spatial and temporal patterning mechanisms provide an efficient model through which…
Hailun Zhu, Sihai Dave Zhao, Alokananda Ray, Yu Zhang + 1 more
During development, neural progenitors are temporally patterned to sequentially generate a variety of neural types. In Drosophila neural progenitors called neuroblasts, temporal patterning is regulated by cascades of Temporal Transcription Factors (TTFs). However, known TTFs were mostly identified through candidate…
Katie H. Long, Justin D. Lieber, Sliman J. Bensmaia
Humans are exquisitely sensitive to the microstructure and material properties of surfaces. In the peripheral nerves, texture information is conveyed via two mechanisms: coarse textural features are encoded in spatial patterns of activation that reflect their spatial layout, and fine features are encoded in highly…
Andrea Lopes, Elia Magrinelli, Ludovic Telley
The complexity of brain structure and function is rooted in the precise spatial and temporal regulation of selective developmental events. During neurogenesis, both vertebrates and invertebrates generate a wide variety of specialized cell types through the expansion and specification of a restricted set of neuronal…
Albert Ali Salah, Eric Pauwels, Romain Tavenard, Theo Gevers
The trend to use large amounts of simple sensors as opposed to a few complex sensors to monitor places and systems creates a need for temporal pattern mining algorithms to work on such data. The methods that try to discover re-usable and interpretable patterns in temporal event data have several shortcomings. We…
Rebecca M Leech, Stephanie E Chappel, Nicola D Ridgers, Heather A Eicher-Miller + 2 more
'Heather A Eicher-Miller' 'Ralph Maddison' 'Sarah A McNaughton'] Dietary and movement behaviors [physical activity (PA), sedentary behavior (SED), and sleep] occur throughout a 24-h day and involve multiple contexts. Understanding the temporal patterning of these 24-h behaviors and their contextual determinants is key…
Peter Cariani, Janet M. Baker
This paper focuses on possible time-domain neurocomputational mechanisms for short-term anticipatory processes. Here we present a simple, signal processing functional model of how short-term rhythmic pattern expectancies could be computed on the fly using recurrent neural timing nets (RTNs). The model is inspired by…
Michael R Bale, Malamati Bitzidou, Anna Pitas, Leonie S Brebner + 5 more
'Lina Khazim' 'Stavros T Anagnou' 'Caitlin D Stevenson' 'Miguel Maravall' 'Ranulfo Romo'] The world around us is replete with stimuli that unfold over time. When we hear an auditory stream like music or speech or scan a texture with our fingertip, physical features in the stimulus are concatenated in a particular…
Peter Cariani, Janet M. Baker
Here we present evidence for the ubiquity of fine spike timing and temporal coding broadly observed across sensory systems and widely conserved across diverse phyla, spanning invertebrates and vertebrates. A taxonomy of basic neural coding types includes channel activation patterns, temporal patterns of spikes, and…
Semir Zeki, Oliver J. Hulme, Barrie Roulston, Michael Atiyah + 1 more
'Ernest Greene'] In the work reported here, we set out to study the neural systems that detect predictable temporal patterns and departures from them. We used functional magnetic resonance imaging (fMRI) to locate activity in the brains of subjects when they viewed temporally regular and irregular patterns produced by…
Janet M. Baker, Peter Cariani
Time is essential for understanding the brain. A temporal theory for realizing major brain functions (e.g., sensation, cognition, motivation, attention, memory, learning, and motor action) is proposed that uses temporal codes, time-domain neural networks, correlation-based binding processes and signal dynamics. It…
Jacob LS Bellmund, Lorena Deuker, Christian F Doeller, Ida Momennejad + 1 more
'Ida Momennejad' 'Timothy E Behrens'] Remembering event sequences is central to episodic memory and presumably supported by the hippocampal-entorhinal region. We previously demonstrated that the hippocampus maps spatial and temporal distances between events encountered along a route through a virtual city (Deuker et…
Sophie Bagur, Jacques Bourg, Alexandre Kempf, Thibault Tarpin + 8 more
'Khalil Bergaoui' 'Yin Guo' 'Sebastian Ceballo' 'Joanna Schwenkgrub' 'Antonin Verdier' 'Jean Luc Puel' 'Jérôme Bourien' 'Brice Bathellier'] The temporal structure of sensory inputs contains essential information for their interpretation. Sensory cortex represents these temporal cues through two codes: the temporal…
Luca Mazzucato, Gordon J Berman, Timothy E Behrens
Naturalistic animal behavior exhibits a strikingly complex organization in the temporal domain, with variability arising from at least three sources: hierarchical, contextual, and stochastic. What neural mechanisms and computational principles underlie such intricate temporal features? In this review, we provide a…