26 papers · ranked by Valyu relevance
Abhijeet R. Sonawane, John Platig, Maud Fagny, Cho-Yi Chen + 6 more
Although all human tissues carry out common processes, tissues are distinguished by gene expres-sion patterns, implying that distinct regulatory programs control tissue-specificity. In this study, we investigate gene expression and regulation across 38 tissues profiled in the Genotype-Tissue Expression project. We find…
Ning Wu, Erwei Sun, Dongfang Liu, Di Yu
Substantial evidence supports the critical role of immune responses in nonlymphoid tissues, including the skin, liver, lung, joint, gut, and tumor [1, 2]. Both innate and adaptive immune cells residing in these tissues regulate local homeostasis and contribute to tissue-specific diseases [3, 4]. Recent reports have…
Girdhari Rijal, Weimin Li
Human connective tissues are complex physiological microenvironments favorable for optimal survival, function, growth, proliferation, differentiation, migration, and death of tissue cells. Mimicking native tissue microenvironment using various three-dimensional (3D) tissue culture systems in vitro has been explored for…
Evelyn Ramberger, Gunnar Dittmar
Mass spectrometry-based proteomics is a powerful tool for identifying and quantifying proteins in biological samples. While it is routinely used for the characterization of simple cell line systems, the analysis of the cell specific proteome in multicellular organisms and tissues poses a significant challenge.…
Diana Domanska, Umair Majid, Victoria T. Karlsen, Marianne A. Merok + 4 more
Macrophages are a heterogeneous population of cells involved in tissue homeostasis, inflammation and cancer. Although macrophages are densely distributed throughout the human intestine, our understanding of how gut macrophages maintain tissue homeostasis is limited. Here we show that colonic lamina propria (LpM) and…
Katelyn Del Toro, Rosalyn W. Sayaman, Kate Thi, Yamhilette Licon-Munoz + 1 more
A fundamental question in biology, central to our understanding of cancer and other pathologies, is determining how different cell types coordinate to form and maintain tissues. Recognizing the distinct features and capabilities of the cells that compose these tissues is critical. Unfortunately, the complexity of…
Matthew Smart, Anton Zilman
Multicellular organisms comprise a diverse collection of stable tissues built from different cell types. It remains unclear how large numbers of interacting cells can precisely coordinate their gene expression during tissue self-organization. We develop a generalized model of multicellular gene expression that includes…
Judith Wienke, Laura Brouwers, Leone van der Burg, Michal Mokry + 4 more
Regulatory T cells (Tregs) are crucial for maintaining immune tolerance against the semi-allogeneic fetus during pregnancy. Since their functional profile at the human maternal-fetal interface is still elusive, we investigated the transcriptional profile and functional adaptation of human uterine Tregs (uTregs) during…
Nicholas Pellegrino, Benjamin R. Ecclestone, Deepak Dinakaran, Frank van Landeghem + 2 more
'Frank van Landeghem' 'Paul Fieguth' 'Parsin Haji Reza'] Photoacoustic Remote Sensing (PARS) microscopy is an emerging label-free optical absorption imaging modality. PARS operates by capturing nanosecond-scale optical perturbations generated by photoacoustic pressures. These time-domain (TD) modulations are usually…
Rumana Rashid, Giorgio Gaglia, Yu-An Chen, Jia-Ren Lin + 8 more
In this data descriptor, we document a dataset of multiplexed immunofluorescence images and derived single-cell measurements of immune lineage and other markers in formaldehyde-fixed and paraffin-embedded (FFPE) human tonsil and lung cancer tissue. We used tissue cyclic immunofluorescence (t-CyCIF) to generate…
John W. Hickey, Elizabeth K. Neumann, Andrea J. Radtke, Jeannie M. Camarillo + 20 more
'Jeannie M. Camarillo' 'Rebecca T. Beuschel' 'Alexandre Albanese' 'Elizabeth McDonough' 'Julia M. Hatler' 'Anne E. Wiblin' 'Jeremy Fisher' 'Joshua Croteau' 'Eliza C. Small' 'Anup Sood' 'Richard M. Caprioli' 'Michael Angelo' 'Garry P. Nolan' 'Kwanghun Chung' 'Stephen M. Hewitt' 'Ronald N. Germain' 'Jeffrey M. Spraggins'…
Benjamin A. Yang, Trisha M. Westerhof, Kaitlyn Sabin, Sofia D. Merajver + 1 more
'Sofia D. Merajver' 'Carlos A. Aguilar'] Title: Abstract All multicellular organisms rely on intercellular communication networks to coordinate physiological functions. As members of a dynamic social network, each cell receives, processes, and redistributes biological information to define and maintain tissue…
Authors not listed
Self-organizing tissues, such as organoids, offer transformative potential beyond healthcare by enabling the sustainable production of advanced materials. Resource scarcity and global warming drive the need for innovative fabrication solutions. This prospective review explores developmental biology as a manufacturing…
Ali Bakhshinejad
The invention of three-dimensional printers has led to major innovations in tissue engineering. They have enabled the printing of complex geometries such as those that occur in natural tissues, that were not possible with traditional manufacturing techniques. Tissue engineering in particular deals with printing…
Afsaneh Taheri Kal-Koshvandi
We present the first light-free, genetically minimal platform for spatiotemporally resolved proximity labeling across five neuronal compartments—synaptic, nuclear, endosomal, mitochondrial, and activity-dependent microdomains. A covalent "catalyst–luciferase sandwich" architecture site-specifically conjugates five…
Kazeem Olanrewaju, Ashlee N. Ford Versypt
The human physiological system consists of several biological units carefully organized to engage in a bio-physicochemical interaction with complex fluids transporting nutritional and life-supporting species (oxygen and carbon dioxide) needed for the proper functioning of the body. The nutritional species are products…
Yutaka Tsutsumi, Atsufumi Kawabata
Chromogenic immunohistochemistry (immunostaining using an enzyme-labeled probe) is an essential histochemical technique for analyzing pathogenesis and making a histopathological diagnosis in routine pathology services. In neoplastic lesions, immunohistochemistry allows the study of specific clinical and biological…
Miriam Bassler, Jonas Hiller, Frank Wackenhut, Sven zur Oven-Krockhaus + 9 more
Malignant primary brain tumors are a group of highly aggressive and often infiltrating tumors that lack adequate therapeutic treatments to achieve long time survival. Complete tumor removal is one precondition to reach this goal. A promising approach to optimize resection margins and eliminate remaining infiltrative…
Saumya Prasad, Anil Chandra, Michèle Cavo, Erika Parasido + 7 more
'Stanley T. Fricke' 'Yichien Lee' 'Eliana D’Amone' 'Giuseppe Gigli' 'Chris Albanese' 'Olga Rodríguez' 'Loretta L. del Mercato'] The tumour microenvironment strongly influences tumorigenesis and metastasis. Two of the most characterized properties of the tumour microenvironment are acidosis and hypoxia, both of which…
Claire Morin, Witold Krasny, Stéphane Avril
The mechanical integrity of arteries is of prime importance, for a proper oxygen and nutrients delivery to all organs. To optimize their mechanical properties, healthy arteries exhibit a complex hierarchical microstructure which ensures a sufficient compliance at low stresses and which stiffens at higher stresses…
Nao Nishida-Aoki, Taranjit S. Gujral
Cell-cell interactions are of crucial importance for tissue formation, homeostasis, regeneration processes, and immune response. Recent studies underlined contribution of cell-cell interaction in tumor microenvironment (TME) for tumor progression and metastasis. Cancer cells modify the host cells to tumor-supportive…
Noor Abu Jarad, Jeffrey I Weitz, Tohid Didar
Improving the performance of blood-contacting medical implants is a global health necessity aimed at reducing mortality and morbidity in patients with cardiovascular diseases. Surface modification of the biomaterials from which the implants are constructed has been used to reduce the risk of complications such as…
Saya Tamura, Takuma Hayashi, Hideki Tokunaga, Nobuo Yaegashi + 2 more
Uterine leiomyoma, also known as fibroids, is the most common benign neoplasm of the female genital tract. Leiomyoma is the most common uterine tumor. The leiomyoma subtypes account for approximately 10% of leiomyomas. Intravenous leiomyomatosis, a uterine leiomyoma subtype, is an intravascular growth of benign smooth…
Authors not listed
Immuno-oncology, a rapidly evolving field at the forefront of cancer research, leverages the body’s immune system to fight cancer. In this follow up report, we extend our natural language processing (NLP)-based analysis to pinpoint the context of emergence of the previously identified emerging concepts. To achieve this…
Sébastien This, Santiago Costantino, Heather J. Melichar
Adoptive T cell therapies rely on the transduction of T cells with a predetermined antigen receptor which redirects their specificity towards tumor-specific antigens. Despite the development of multiple platforms for tumor-specific T cell receptor (TCR) discovery, this process remains time consuming and skewed toward…
Matteo Turetta, Fabio Del Ben, Giulia Brisotto, Eva Biscontin + 6 more
'Michela Bulfoni' 'Daniela Cesselli' 'Alfonso Colombatti' 'G. Scoles' 'Giuseppe Gigli' 'Loretta L. del Mercato'] a Istituto di Anatomia Patologica, Dipartimento di Scienze Mediche e Biologiche, Azienda Sanitaria Universitaria Integrata di Udine, 33100 Udine, Italia; b Patologia Clinica Oncologica, Oncologia…