24 papers · ranked by Valyu relevance
Mahasweta Das, Subhra Mohapatra, Shyam S Mohapatra
Traumatic injury to the brain (TBI) results in a complex set of responses involving various symptoms and long-term consequences. TBI of any form can cause cognitive, behavioral and immunologic changes in later life, which underscores the problem of underdiagnosis of mild TBI that can cause long-term neurological…
Alexander Muacevic, John R Adler, Shivangi Jha, Prajakta Ghewade
Traumatic brain injuries (TBI) are one of the main reasons for death in recent years worldwide or globally. They are the number one cause of death for both civilians and military members. It affects how the brain functions and is currently one of the crucial concerns of global public health issues. TBI is increasing…
Amy Yan, Andrew Torpey, Erin Morrisroe, Wesam Andraous + 4 more
'Sergio Bergese' 'Juan Sahuquillo' 'Arjun Sapkota'] Traumatic brain injury is one of the leading causes of morbidity and mortality worldwide and is one of the major public healthcare burdens in the US, with millions of patients suffering from the traumatic brain injury itself (approximately 1.6 million/year) or its…
Aldrich Chan, Jason Ouyang, Kristina Nguyen, Aaliyah Jones + 2 more
'Sophia Basso' 'Ryan Karasik'] The best predictor of functional outcome in victims of traumatic brain injury (TBI) is a neuropsychological evaluation. An exponential growth of research into TBI has focused on diagnosis and treatment. Extant literature lacks a comprehensive neuropsychological review that is…
Stuart J. McDonald, Mujun Sun, Denes V. Agoston, Sandy R. Shultz
Background Traumatic injuries are physical insults to the body that are prevalent worldwide. Many individuals involved in accidents suffer injuries affecting a number of extremities and organs, otherwise known as multitrauma or polytrauma. Traumatic brain injury is one of the most serious forms of the trauma-induced…
Satoshi Yamamoto, Douglas S. DeWitt, Donald S. Prough
Traumatic brain injury (TBI) is one of the most frequent causes of combat casualties in Operations Iraqi Freedom (OIF), Enduring Freedom (OEF), and New Dawn (OND). Although less common than combat-related blast exposure, there have been significant numbers of blast injuries in civilian populations in the United States.…
Zachary M. Weil, John D. Corrigan, Kate Karelina
Alcohol use and traumatic brain injury (TBI) are inextricably and bidirectionally linked. Alcohol intoxication is one of the strongest predictors of TBI, and a substantial proportion of TBIs occur in intoxicated individuals. An inverse relationship is also emerging, such that TBI can serve as a risk factor for, or…
Luqmanul Hakim Abdul Razak, Tedd Denis, Yoghaanjaly Murugiah, Weng Kei Yoong + 2 more
'Weng Kei Yoong' 'Zamzuri Idris' 'Mohd Harizal Senik'] Having a good memory is essential for carrying out daily tasks. People cannot study, plan, remember or navigate life effectively if they are memoryless. People may be at risk when mistakes made in the past will be repeated and lessons regarding danger cannot be…
Hossein Bahreinizad, Suman K. Chowdhury
This study aimed to investigate the role of neck muscle activity and neck damping characteristics in traumatic brain injury mechanisms. We used a previously validated head-neck finite element model, incorporating various components such as scalp, skull, cerebrospinal fluid, brain, neck muscles, ligaments, cervical…
Monique C. Surles-Zeigler, Troy Sincomb, C Edward Dixon, Fahim Imam + 4 more
Traumatic brain injury (TBI) is an insult to the brain resulting from an external force and is a significant cause of morbidity and mortality in the United States. No effective clinical therapeutics currently exist for this injury. Although several therapies and procedures have been deemed successful for TBI treatment…
Babak Moghadas, Vimala N. Bharadwaj, John P. Tobey, Yanqing Tian + 2 more
In this study, we use the hypoxia targeting agent (GdDO3NI, a nitroimidazole-based T_1_ MRI contrast agent) for imaging hypoxia in the injured brain after experimental traumatic brain injury (TBI) using magnetic resonance imaging (MRI), and validate the results with immunohistochemistry (IHC) using pimonidazole. TBI…
Haym Benaroya
As neuroscience makes rapid progress in mapping causes and effects at subcellular, cellular, tissue and system levels, the time may be ripe for increased efforts at the mathematical modeling of these causes and effects. Descriptive understanding is extremely valuable, but these tend to be snapshots of coupled and…
Hanem Ellethy, Shekhar S. Chandra, Viktor Vegh
Traumatic Brain Injury (TBI) poses a significant global public health challenge, contributing to high morbidity and mortality rates and placing a substantial economic burden on healthcare systems worldwide. The diagnosis of TBI relies on clinical information along with Computed Tomography (CT) scans. Addressing the…
Ashley C. Bolte, Mariah E. Hurt, Igor Smirnov, Michael A. Kovacs + 7 more
Traumatic brain injury (TBI) has emerged as a leading cause of death and disability. Despite being a growing medical issue, the biological factors that promote central nervous system (CNS) pathology and neurological dysfunction following TBI remain poorly characterized. Recently, the meningeal lymphatic system was…
Tamás Kovács-Öller, Renáta Zempléni, Boglárka Balogh, Gergely Szarka + 7 more
Traumatic brain injury (TBI) is among the main causes of sudden death after head trauma. These injuries can result in severe degeneration and neuronal cell death in the CNS, including the retina which is a crucial part of the brain responsible for perceiving and transmitting visual information. The long-term effects of…
Lauren J Putnam, Ashley M Willes, Brooke E Kalata, Nathaniel D Disher + 1 more
Several million traumatic brain injury (TBI) events are reported in the United States annually. However, mild TBI events often go unreported, and mild and repetitive mild TBI conditions are challenging to model. Fruit flies have gained traction for the study of TBI. The best-characterized fly TBI model is the…
Eric G. Blackman, Melina E. Hale, Sarah H. Lisanby
How well do current combat helmets protect against Traumatic Brain Injury? To answer this question it is necessary to evaluate both the measures and standards of protection. We define measure as a physical test that the helmet must be subject to and the standard as the quantitative threshold of performance in this test…
Jessica Towns, Cecchi, Nicholas J., James W. Hickey + 9 more
1Department of Bioengineering, Stanford University, Stanford, CA 2Dyson School of Design Engineering, Imperial College London, London, UK 3Department of Neuroscience, School of Translational Medicine, Monash University, Melbourne, VIC 4Centre for Sport Research, Institute for Physical Activity and Nutrition, Deakin…
Y. Wan, Rafael D. González-Cruz, Diane Hoffman–Kim, Haneesh Kesari
Brain injuries resulting from mechanical trauma represent an ongoing global public health issue. Several in vitro and in vivo models for traumatic brain injury (TBI) continue to be developed for delineating the various complex pathophysiological processes involved in its onset and progression. Developing an in vitro…
Mahnaz Tajik, Michael D Noseworthy
a. School of Biomedical Engineering, McMaster University, 1280 Main St W, Hamilton, ON, Canada; b. Imaging Research Centre, St. Joseph's Healthcare Hamilton, 50 Charlton Ave E, Hamilton, ON, Canada; c. Department of Medical Sciences, McMaster University, 1280 Main St W, Hamilton, ON, Canada d. Department of Electrical…
Xianghao Zhan, Yuzhe Liu, Nicholas J. Cecchi, Olivier Gevaert + 3 more
'Michael Zeineh' 'Gerald A. Grant' 'David B. Camarillo'] Abstract—Objective: Strain and strain rate are effective traumatic brain injury predictors. Kinematics-based models estimating these metrics suffer from significant different distributions of both kinematics and the injury metrics across head impact types. To…
Nicole J. Katchur, Jessica Yeager, Lisa Schneper, Hacer Savas + 1 more
Traumatic brain injury (TBI) is a public health burden with short-term and long-term consequences for those who survive. Repetitive TBI (rTBI) is highly associated with neurodegenerative diseases such as chronic traumatic encephalopathy. Here, we present a force-adjustable, enhanced CO_2_-driven Drosophila model of…
James T. Neal, Aimee Bertolli, Georgina M Aldridge, Eric B. Emmons
Traumatic brain injuries (TBIs) result from impact to or rapid displacement of the brain and can lead to various neurological deficits involving working memory, decision-making, and anxiety. While large-scale effects of brain damage are well-described for more severe TBIs, less is known about the extent and duration of…
Authors not listed
Microglia, the innate immune cells of the central nervous system (CNS), act as first responders in the context of brain injury or neurodegeneration. Their ability to switch between different neuroprotective and neurotoxic phenotypes, plays a central role in maintaining brain homeostasis. Recently, the P2Y12 receptor…