27 papers · ranked by Valyu relevance
Winnie M. C. van den Boogaard, Daphne S. J. Komninos, Wilbert P. Vermeij, Ana María Zubiaga + 1 more
'Wilbert P. Vermeij' 'Ana María Zubiaga' 'Jone Mitxelena'] Simple Summary The number of children and adults with cancer that are completely cured is still increasing thanks to effective anti-cancer therapy, but they may be confronted with the negative lasting effects of the treatment later in life. In this review, we…
Eun Mi Lee, Paula Jiménez-Fonseca, Rocio Galán-Moral, Sara Coca-Membribes + 7 more
'Sara Coca-Membribes' 'Ana Fernández-Montes' 'Elena Sorribes' 'Esmeralda García-Torralba' 'Laura Puntí-Brun' 'Mireia Gil-Raga' 'Juana Cano-Cano' 'Caterina Calderon'] The purpose of the study was to identify subgroups of advanced cancer patients who experienced grade 3-4 toxicities as reported by their oncologists as…
Jana L. Gevertz, Harsh Vardhan Jain, Irina Kareva, Kathleen P. Wilkie + 5 more
Cancer therapies often fail when intolerable toxicity or drug-resistant cancer cells undermine otherwise effective treatment strategies. Over the past decade, adaptive therapy has emerged as a promising approach to postpone emergence of resistance by altering dose timing based on tumor burden thresholds. Despite…
Eleonore Fröhlich, Dirk Steinritz
Toxicity in humans may occur by exposure to natural (toxins) and manufactured subtances and products (toxicants). These substances cause damage to the organism either by contact with epithelial barriers such as mucosae and skin or by the parenteral route (inhalation or ingestion). In addition to these substances with…
Hui Yan, Penggao Wang, Fang Yang, Weyland Cheng + 3 more
'Bo Zhai' 'Yang Zhou'] In recent years, considerable achievements have been made in pediatric oncology with the innovation and development of antitumor drugs. However, compared to adults, children as a special group have not yet matured fully in terms of liver and kidney function. Moreover, pediatric patients are prone…
David C. Norris
I have previously evaluated the efficiency of one-size-fits-all dosing for single agents in oncology (5). By means of a generic argument based on an E_max_-type dose-response model, I showed that one-size-fits-all dosing may roughly halve a drug’s value to society. Since much of the past decade’s ‘innovation’ in…
Arman Ahmadzadeh, Nasim Zamani, Hossein Hassanian-Moghaddam, Seyed Kaveh Hadeiy + 1 more
'Seyed Kaveh Hadeiy' 'Parinaz Parhizgar'] Background Data is limited on comparison of acute and chronic methotrexate (MTX) poisoning. Methotrexate is an anti-folate drug that may be prescribed in some malignant or chronic inflammatory conditions. The aim of the current study was to compare signs and symptoms…
Marta Spreafico, Francesca Ieva, Marta Fiocco
In cancer trials, the analysis of longitudinal toxicity data is a difficult task due to the presence of multiple adverse events with different extents of toxic burden. Models able to summarise and quantify the overall toxic risk and its evolution during cancer therapy, which deals with both the longitudinal and the…
Malek Chennoufi, Dorra Dridi, Khaled Lasram, Nouha Ben Abdeljalil + 2 more
Ifosfamide (IFO) is an effective chimiotherapeutic agent for sarcomas and germ-cell tumors but its clinical use is limited by severe toxicities, particularly hemorrhagic cystitis and encephalopathy. We recently demonstrated that IFO displays a circadian rhythm of lethal toxicity at LD50, with survival, body weight loss…
Authors not listed
Fluoroquinolones (FQs) are an important class of potent broad-spectrum antibiotics. However, their general use is more and more limited by adverse side effects. While general mechanisms for the fluoroquinolone-associated disability (FQAD) have been identified, the underlying molecular targets of toxicity remain…
Emma Gerard, Sarah Zohar, Hoai‐Thu Thai, Christelle Lorenzato + 2 more
'Marie‐Karelle Riviere' 'Moreno Ursino'] Phase I dose-finding trials in oncology seek to find the maximum tolerated dose (MTD) of a drug under a specific schedule. Evaluating drug-schedules aims at improving treatment safety while maintaining efficacy. However, while we can reasonably assume that toxicity increases…
Temitayo Ajayi, Seyedmohammadhossein Hosseinian, Andrew J. Schaefer, Clifton D. Fuller
'Clifton D. Fuller'] Chemotherapy is one of the primary modalities of cancer treatment. Chemotherapy drug administration is a complex problem that often requires expensive clinical trials to evaluate potential regimens. One way to alleviate this burden and better inform future trials is to build reliable models for…
Narsis A. Kiani, Ming-Mei Shang, Héctor Zenil, Jesper Tegnér
| 1 Unit | of | Computational | | Medicine, | Center | for | Molecular | | Medicine, | Department | of | Medicine, | Solna, | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | | Karolinska | | Institutet, | Stockholm, | 171 | 76, | Sweden | | | | | | | | | | 2 Algorithmic…
Batool Wali, Niga Othman, Sara Rashid, Sima Hamid + 1 more
This paper provides an overview of the environmental and safety concerns associated with benzalkonium chloride (BAC), a chemical widely used in pharmaceuticals. The review covers BAC's various applications, toxicity, and environmental considerations. It explores the industrial processing of BAC, its role as a…
Authors not listed
Methicillin-resistant Staphylococcus aureus (MRSA) is one of a leading cause of antibiotic-resistant bacterial infections. Based on our previous findings, we utilized thiazole-fused nootkatone hit compounds to develop a simple phenol-substituted thiazole scaffold as potent antibacterial agents, particularly active…
Dana Klug, Edwin Tse, Daniel Silva, Yafeng Cao + 29 more
Antimicrobial resistance (AMR) is widely acknowledged as one of the most serious public health threats facing the world, yet the private sector finds it challenging to generate much-needed medicines. As an alternative discovery approach, a small array of diarylimidazoles was screened against the ESKAPE pathogens…
Luis A. Fernández, Cécilia Pola, Judith Sáinz-Pardo Díaz
Since the origins of chemotherapy in oncology, the standard and most widely used treatment has been the maximum tolerated dose (MTD) one: "the higher the dose, the better", whose rationale seems very intuitive. As everyone knows, the trade-off lies in the side effects due to drug toxicity, which not only diminishes…
Ramprakash Kaswa
The impact of poisoning can differ significantly depending on the specific substance consumed. Identifying toxic substances in a patient is crucial to obtaining a thorough medical history. Frontline healthcare providers in the emergency department often handle patients presenting with poisoning. Their clinical…
Álvaro G. López, Kelly C. Iarosz, Antônio M. Batista, Jesús M. Seoane + 2 more
'Jesús M. Seoane' 'Ricardo L. Viana' 'Miguel A. F. Sanjuán'] A multicompartment mathematical model is presented with the goal of studying the role of dose-dense protocols in the context of combination cancer chemotherapy. Dose-dense protocols aim at reducing the period between courses of chemotherapy from three to two…
David N. Phalen, Angela Frimberger, Stephen Pyecroft, Sarah Peck + 7 more
'Colette Harmsen' 'Suzanneth Lola' 'Beatriz de Mello Mattos' 'Kong M. Li' 'Andrew J. McLachlan' 'Antony Moore' 'Gerard Roel Rutteman'] Tasmanian Devil Facial Tumor Disease (DFTD) is a transmissible cancer threatening to cause the extinction of Tasmanian Devils in the wild. The aim of this study was to determine the…
Muneera Al-Jelaify, Suliman AlHomidah
Acute poisoning is a widespread emergency that mandates early management decisions for optimal outcomes. An individualized approach is an ideal way to provide those outcomes. Promoting awareness among healthcare professionals managing acute poisoning about the importance of incorporating the pharmacokinetics and…
Timm O. Koller, Ullrich Scheid, Teresa Kösel, Jennifer Herrmann + 23 more
Resistance of bacterial pathogens against antibiotics is declared by WHO as a major global health threat. As novel antibacterial agents are urgently needed, we re-assessed the broad-spectrum myxobacterial antibiotic myxovalargin and found it to be extremely potent against Mycobacterium tuberculosis. To ensure compound…
Álvaro G. López, Kelly C. Iarosz, Antônio M. Batista, Jesús M. Seoane + 2 more
'Jesús M. Seoane' 'Ricardo L. Viana' 'Miguel A. F. Sanjuán'] aNonlinear Dynamics, Chaos and Complex Systems Group. Departamento de F´ısica, Universidad Rey Juan Carlos, Tulipan s/n, 28933 M ´ ostoles, Madrid, ´ Spain b Instituto de F´ısica, Universidade de Sao Paulo, 05315-970 S ˜ ao Paulo, SP, Brazil ˜ cDepartamento…
Liping Zhang, Ben Zhong Tang, Zheng Zhao, Yu Xiong + 8 more
Targeted and controllable drug release at lesion sites with the aid of visual navigation in real-time is of great significance for precise theranostics of cancers. Benefiting from the marvellous features (e.g. bright emission and phototheranostic effect in aggregates) of aggregation-induced emission (AIE) materials…
Troy Day, Andrew F. Read
High-dose chemotherapy has long been advocated as a means of controlling drug resistance in infectious diseases but recent empirical and theoretical studies have begun to challenge this view. We show how high-dose chemotherapy engenders opposing evolutionary processes involving the mutational input of resistant strains…
Marlene Jara, Jorge Arevalo, Alejandro Llanos, Frederik Van den Broeck + 2 more
Resistance against anti-Leishmania drugs (DR) has been studied for years, giving important insights into long-term adaptations of these parasites to drugs, through genetic modifications. However, microorganisms can also survive lethal drug exposure by entering into temporary quiescence, a phenomenon called drug…
HACHEMI KADRI, Mesk Alshatfa, Feras Z Alsalloum, Abdelbary Elhissi + 2 more
Cancer, a global health burden, is characterized by uncontrolled cell growth and metastasis, often resulting in debilitating treatments and mortality. While conventional therapeutic strategies have improved survival rates, they are limited by challenges such as off-target toxicity and drug resistance. With their design…