24 papers · ranked by Valyu relevance
Consuelo Pitolli, Ying Wang, Eleonora Candi, Yufang Shi + 2 more
'Gerry Melino' 'Ivano Amelio'] The tumor suppressor p53 regulates different cellular pathways involved in cell survival, DNA repair, apoptosis, and senescence. However, according to an increasing number of studies, the p53-mediated canonical DNA damage response is dispensable for tumor suppression. p53 is involved in…
Kathleen Schmit, Carine Michiels
A transmembrane protein (TMEM) is a type of protein that spans biological membranes. Many of them extend through the lipid bilayer of the plasma membrane but others are located to the membrane of organelles. The TMEM family gathers proteins of mostly unknown functions. Many studies showed that TMEM expression can be…
Yogesh Saini, Jian Chen, Sonika Patial
Post-transcriptional regulation of gene expression plays a key role in cellular proliferation, differentiation, migration, and apoptosis. Increasing evidence suggests dysregulated post-transcriptional gene expression as an important mechanism in the pathogenesis of cancer. The tristetraprolin family of RNA-binding…
Hiroyuki Kugoh, Takahito Ohira, Mitsuo Oshimura, Gabi Dachs
The development and progression of malignant tumors likely result from consecutive accumulation of genetic alterations, including dysfunctional tumor suppressor genes. However, the signaling mechanisms that underlie the development of tumors have not yet been completely elucidated. Discovery of novel tumor-related…
Lei Qiu, Zelong Ma, Xiaoming Wu, Maciej Wnuk
The tumor secretome comprises the totality of protein factors secreted by various cell components within the tumor microenvironment, serving as the primary medium for signal transduction between tumor cells and between tumor cells and stromal cells. The deletion or mutation of the p53 gene leads to alterations in…
Massimiliano Mazza, Pier Giuseppe Pelicci
The role of the promyelocytic leukemia (PML) protein has been widely tested in many different contexts, as attested by the hundreds of papers present in the literature. In most of these studies, PML is regarded as a tumor suppressor, a notion on the whole accepted by the scientific community. In this review, we examine…
Ayad Ghany Ismaeel
— Tumor protein P53 is believed to be involved in over half of human cancers cases, the prediction of malignancies plays essential roles not only in advance detection for cancer, but also in discovering effective prevention and treatment of cancer, till now there isn't approach be able in prediction the mutated in…
Alicja Sznarkowska, Anna Kostecka, Katarzyna Koczergo, Anna Kawiak + 4 more
The p73 protein is a tumor suppressor that shares structural and functional similarity with p53. p73 is expressed in two major isoforms; the TA isoform that interacts with p53 pathway, thus acting as tumor suppressor and the N-terminal truncated ΔN isoform that inhibits TAp73 and p53 and thus, acts as an oncogene. By…
Manish Kumar
Cancer is a complex disease having a number of composite problems to be considered including cancer immune evasion, therapy resistance, and recurrence for a cure. Fundamentally, it remains a genetic disease as diverse aspects of the complexity of tumor growth and cancer development relate to its genetic machinery and…
Aziz Aiderus, Ana M. Contreras-Sandoval, Amanda L. Meshey, Justin Y. Newberg + 6 more
A central challenge in cancer genomics is the systematic identification of single and cooperating tumor suppressor genes driving cellular transformation and tumor progression in the absence of oncogenic driver mutation(s). Multiple in vitro and in vivo gene inactivation screens have enhanced our understanding of the…
Farruk M. Lutful Kabir, Carlos E. Alvarez, R. Curtis Bird, Jaime Modiano
'Jaime Modiano'] Breast cancer represents the second most frequent neoplasm in humans and sexually intact female dogs after lung and skin cancers, respectively. Many similar features in human and dog cancers including, spontaneous development, clinical presentation, tumor heterogeneity, disease progression and response…
Patricia Lado-Fernández, Jéssica M Vilas, Tânia Fernandes, Carmen Carneiro + 10 more
During cancer development and progression, many genetic alterations lead to the acquisition of novel features that confer selective advantage to cancer cells and that resemble developmental programs. SOX2 is one of the key pluripotency transcription factors, expressed during embryonic development and active in adult…
Abderrahim Chafik
In contrary to the common belief that only one strand of the premiRNA is active (usually the 5p one that is the more abundant) while the second one (miRNA*) is discarded, functional 5p and 3p have been observed for many miRNAs. Among those miRNAs is miR-34a which is a target gene of the tumor suppressor p53. In this…
Xiangmudong Kong, Wensheng Yan, Wenqiang Sun, Yanhong Zhang + 6 more
TP73, a member of the p53 family, is expressed as TAp73 and ΔNp73 along with multiple C-terminal isoforms (α−η). ΔNp73 is primarily expressed in neuronal cells and necessary for neuronal development. Interestingly, while TAp73α is a tumor suppressor and predominantly expressed in normal cells, TAp73 is found to be…
Jess D. Hebert, Yuning J. Tang, Laura Andrejka, Steven S. Lopez + 3 more
Lung adenocarcinoma, the most common subtype of lung cancer, is genomically complex, with tumors containing tens to hundreds of non-synonymous mutations. However, little is understood about how genes interact with each other to enable tumorigenesis in vivo, largely due to a lack of methods for investigating genetic…
J. Roberto Romero-Arias, Guillermo Ramírez-Santiago, Jorge X. Velasco-Hernández, Laurel Ohm + 1 more
We present and analyze a growth model of an avascular tumor that considers the basic biological principles of proliferation, motility, death and genetic mutations of the cell. From a regulatory network analysis and an analysis of genomic data we identify two sets of genes-a set of six genes and a set of sixteen…
Rédoane Daoudi
It is obvious that both epigenetic and non-epigenetic actors contribute to tumorigenesis in chondrosarcomas and more generally in other cancers. Thus, the main altered pathways in chondrosarcomas are now well established and include both epigenetic and non-epigenetic pathways such as the PI3K-AKT signaling, EGFR…
Jorge A. González, M. Acanda, Zubair Akhtar, David Andrews + 15 more
'Jose Ignacio Azqueta' 'Eleanor M. Bass' 'A. Bellorín' 'Juan-Pablo Couso' 'Mónica A. García-Ñustes' 'Yanelys Cabrera Infante' 'S Jiménez' 'Laura Lester' 'Leonel Maldonado' 'Juan F. Marín' 'Lenin Barajas Pineda' 'Inmaculada Rodríguez' 'C. C. Tamayo' 'Diandra Valdes' 'Lourdes Vázquez'] We investigate a new dynamical…
Authors not listed
The WRN helicase has recently emerged as a promising therapeutic target for microsatellite instability (MSI)-high cancers. Here, we report LXW-P1, a potent WRN degrader derived from marine bromotyrosine alkaloids. Its molecular target was identified using an AI-guided, pathway-informed perturbation transcriptomics…
Authors not listed
Neuroblastoma (NB) is the most common tumor of nerve tissue and is the most common cancer in babies. The oncogene MYCN gets amplified in the disease, which can be inhibited by targeting the BRD4 protein.[1] PROTAC, a protein degradation tool, is an emerging therapeutic strategy that targets disease-causing proteins.[2]…
Authors not listed
A substantial and growing body of research implicates protein‑arginine methyltransferases (PRMTs) in the pathogenesis of a range of human diseases, most prominently cancer. Their role – as oncoproteins or tumor suppressors – depends on both the cellular context and the specific type of malignancy. Starting from…
Weizhi Wang, Limin Zhang
Blocking programmed cell death ligand 1 (PD-L1) in tumor cells is an effective therapy strategy to achieve immune system activation for tumor therapy, however only a few patients can benefit from it. Development of synergistic therapy with checkpoint PD-L1 blockade immunotherapy is beneficial to enhance antitumor…
Authors not listed
Proteolysis-targeting chimeras (PROTACs) have recently gained popularity as targeted protein degradation (TPD) promises to overcome the limitations of occupancy-driven pharmacology. However, most degraders rely on a small number of E3 ligases. In this study, we present the first-in-class histone deacetylase (HDAC)…
Authors not listed
Immuno-oncology, a rapidly evolving field at the forefront of cancer research, leverages the body’s immune system to fight cancer. In this follow up report, we extend our natural language processing (NLP)-based analysis to pinpoint the context of emergence of the previously identified emerging concepts. To achieve this…