22 papers · ranked by Valyu relevance
Megen C. Wittling, Shannon R. Cahalan, Eric A. Levenson, Ronald L. Rabin
'Ronald L. Rabin'] Type I interferons (IFN-I) were first discovered as an antiviral factor by Isaacs and Lindenmann in 1957, but they are now known to also modulate innate and adaptive immunity and suppress proliferation of cancer cells. While much has been revealed about IFN-I, it remains a mystery as to why there are…
Deann T. Snyder, Jodi F. Hedges, Mark A. Jutila
Type I interferons represent a unique and complex group of cytokines, serving many purposes during innate and adaptive immunity. Discovered in the context of viral infections, type I IFNs are now known to have myriad effects in infectious and autoimmune disease settings. Type I IFN signaling during bacterial infections…
Michael G. Tovey, Christophe Lallemand
Interferons (IFNs) are class II cytokines that are key components of the innate immune response to virus infection. Three IFN sub-families, type I, II, and III IFNs have been identified in man, Recombinant analogues of type I IFNs, in particular IFNα2 and IFNβ1, have found wide application for the treatment of chronic…
Mingjie Qiu, Jiayang Li, Wenqi Wu, Jianan Ren + 2 more
'Jorge E. Vidal'] Title: ABSTRACT Type I interferons (IFNs) are crucial components of the human immune system, playing a key role in regulating immune activity. Existing literature has characterized their antiviral and proviral roles in viral contexts. Type I IFNs also exhibit a dual role in bacterial infections…
Victoria Urin, Doron Levin, Nanaocha Sharma, Daniel Harari + 2 more
'Gideon Schreiber' 'Martin Fernandez-Zapico'] Type I interferons are multi-potent cytokines that serve as first line of defense against viruses and other pathogens, posses immunomudolatory functions and elicit a growth inhibitory response. In recent years it has been shown that interferons are also detrimental, for…
Emily M. Eshleman, Laurel L. Lenz
Type I interferons (IFNs) were first described for their ability to protect the host from viral infections and may also have beneficial effects under specific conditions within some bacterial infections. Yet, these pleiotropic cytokines are now known to exacerbate infections by numerous life-threatening bacteria…
Zehra Karakoese, Martha Ingola, Barbara Sitek, Ulf Dittmer + 2 more
'Kathrin Sutter' 'Oliver T. Fackler'] Type I interferons (IFN), immediately triggered following most viral infections, play a pivotal role in direct antiviral immunity and act as a bridge between innate and adaptive immune responses. However, numerous viruses have evolved evasion strategies against IFN responses…
Chilakamarti V. Ramana
Type I interferons (IFN α/β) play a central role in innate immunity to respiratory viruses, including coronaviruses. Genetic defects in type I interferon signaling were reported in a significant proportion of critically ill CoOVID-19 patients. Extensive studies on interferon-induced intracellular signal transduction…
Chilakamarti V. Ramana
Respiratory virus infection is one of the leading causes of death in the world. Activation of the Jak-Stat pathway by Interferon-alpha/beta (IFN-α/β) in lung epithelial cells is critical for innate immunity to respiratory viruses. Genetic and biochemical studies have shown that transcriptional regulation by IFN-α/β…
Johnny Castillo Cabrera, Hong Dang, Zhigang Zhang, Jose Torres-Castillo + 6 more
The STING signaling pathway is essential for the innate immune response to DNA viruses and bacteria and is important in tumor immunity. STING binding to cGAMP or to synthetic agonists leads to the activation of the kinase TBK1 which phosphorylates the transcription factor IRF3 which promotes expression of type 1…
Lei Yang, Jeak Ling Ding
Type I interferons are a family of pleiotropic cytokines that exert anti-tumor actions directly on tumor cells and indirectly on the tumor immune microenvironment (TIME). Hitherto, therapeutic strategies aiming to garner the efficacies of interferon responses are still limited. Here we show a novel strategy that…
Xiaobing Deng, Xiaoyu Yu, Jianfeng Pei
Regulating the upstream of the cytokines production could be a promising strategy to the treatment of COVID-19. We suggest to pay more attention to the dysregulated IFN-I production in COVID-19 and to considerate cGAS, ALK and STING as potential therapeutic targets preventing cytokine storm. Approved drugs like suramin…
Farzad Fatehi, Yuliya N. Kyrychko, Konstantin B. Blyuss
A new detailed mathematical model for dynamics of immune response to hepatitis B is proposed, which takes into account contributions from innate and adaptive immune responses, as well as cytokines. Stability analysis of different steady states is performed to identify parameter regions where the model exhibits…
Ana Carolina Arcanjo, Giovanni Mazzocco, Silviene Fabiana de Oliveira, Dariusz Plewczyński + 1 more
'Dariusz Plewczyński' 'Jan P. Radomski'] ADCC – antibody-dependent cell-mediated cytotoxicity AM – alveolar macrophage APC – antigen-presenting cell ASC – apoptosis-associated speck-like protein ASL – airway surface liquid C1QBP – component 1 binding protein CARD – caspase activation and recruitment domain CD32 – cell…
Manal Abdel-Fattah, Hesham Saeed, Lamiaa El-Shennawy, Manal Shalaby + 4 more
The current study highlights for the first time cloning, overexpression, purification, and assessing the cytotxcity of the novel interferon epsilon (IFNε), from the Arabian camel Camelus dromedarius, against two human breast cancer cell lines MDA-MB-231 and MCF-7. Full-length cDNA encoding interferon epsilon (IFNε) was…
Julian Ivanov, Rumiana Tenchov, Krittika Ralhan, Kavita Iyer + 2 more
TBK1, or TANK-binding kinase 1, is an enzyme that functions as a serine/threonine protein kinase. It plays a crucial role in various cellular processes, including the innate immune response to viruses, cell proliferation, apoptosis, autophagy, and anti-tumor immunity. Dysregulation of TBK1 activity can lead to…
Joseph Malinzi, Amina Eladdadi, Rachid Ouifki, Raluca EFTIMIE + 2 more
We present a mathematical model that describes the synergistic mechanism of combined Vesicular Stomatitis Virus (VSV) and Vaccinia Virus (VV). The model captures the dynamic interplay between tumor cells, viral replication, and the interferon-mediated immune response, revealing a 'ping-pong' synergy where VV-infected…
Aram Shaldzhyan, Nikita Yolshin, Yana Zabrodskaya, Tatiana Kudling + 7 more
Type III interferons exhibit antiviral activity against influenza viruses, coronaviruses, rotaviruses, and others. In addition, this type of interferon theoretically has therapeutic advantages, in comparison with type I interferons, due to its ability to activate a narrower group of genes in a relatively small group of…
Wiktor Prus, Frederic Grabowski, Paulina Koza, Zbigniew Korwek + 3 more
Type III interferons (IFN-λ1–λ4) are known to limit influenza virus infections in vivo and are non-redundant to type I interferons (IFN-α and IFN-β). Here, we demonstrated in vitro that type III interferons limit infection with influenza A virus (IAV) independently of STAT1 and STAT2 activation. Despite the fact that…
liu wenzhong, li hualan
Lipopolysaccharide activates the natural immune system response in obese and diabetic patients’ adipose tissue and increases the risk of susceptibility and severity of COVID-19. In this study, bioinformatics techniques such as domain search and molecular docking were used to study the relationship between the ORF7a…
Leticia Paiva, Hallan S Silva, Silvio C. Ferreira, Marcelo L. Martins
'Marcelo L. Martins'] Abstract. Oncolytic virotherapy - the use of viruses that specifically kill tumor cells - is an innovative and highly promising route for treating cancer. However, its therapeutic outcomes are mainly impaired by the host immune response to the viral infection. In the present work, we propose a…
Kyle Macauslane, Cassandra Pegg, Kirsty Short, Benjamin Schulz
Acute respiratory infections (ARIs) are amongst the leading causes of death and disability, and the greatest burden of disease impacts children, pregnant women, and the elderly. Respiratory viruses account for the majority of ARIs. The unfolded protein response (UPR) is a host homeostatic defence mechanism primarily…