21 papers · ranked by Valyu relevance
Helena Dolphin, Tim Dukelow, Ciaran Finucane, Sean Commins + 2 more
The vagus nerve is the longest nerve in the human body, providing afferent information about visceral sensation, integrity and somatic sensations to the CNS via brainstem nuclei to subcortical and cortical structures. Its efferent arm influences GI motility and secretion, cardiac ionotropy, chonotropy and heart rate…
Mario Perelló, María P. Cornejo, Pablo N. De Francesco, Gimena Fernandez + 2 more
'Gimena Fernandez' 'Laurent Gautron' 'Lesly S. Valdivia'] Ghrelin is a stomach-derived peptide hormone that acts via the growth hormone secretagogue receptor (GHSR) and displays a plethora of neuroendocrine, metabolic, autonomic and behavioral actions. It has been proposed that some actions of ghrelin are exerted via…
Nicole Thompson, Svetlana Mastitskaya, David Holder
Title: Highlights 1. • The vagus nerve provides innervation to the majority of the visceral organs. 2. • There is a need to delineate fascicular anatomy to avoid off-target effects of VNS. 3. • Neuronal tracing is a powerful tool to study fascicular organization.
Lijuan Li, Dong Wang, Hongxia Pan, Liyi Huang + 3 more
'Quan Wei'] Stroke poses a serious threat to human health and burdens both society and the healthcare system. Standard rehabilitative therapies may not be effective in improving functions after stroke, so alternative strategies are needed. The FDA has approved vagus nerve stimulation (VNS) for the treatment of…
Crystal M. Noller, Yaakov A. Levine, Timur M. Urakov, Joshua P. Aronson + 1 more
'Joshua P. Aronson' 'Mark S. Nash'] Over the last several decades, vagus nerve stimulation (VNS) has evolved from a treatment for select neuropsychiatric disorders to one that holds promise in treating numerous inflammatory conditions. Growing interest has focused on the use of VNS for other indications, such as heart…
Mikaela Patros, Shobi Sivathamboo, Hugh D. Simpson, Terence J. O'Brien + 1 more
"Terence J. O'Brien" 'Vaughan G. Macefield'] Title: Abstract The vagus nerve is the longest cranial nerve, with much of its territory residing outside the head, in the neck, chest and abdomen. Although belonging to the parasympathetic division of the autonomic nervous system, it is dominated by sensory axons…
Kathryn S. Mirandette, Atharva Sahasrabudhe, Magdalena Slowikowski, John H Caldwell + 3 more
To determine how selective optogenetic vagus nerve stimulation (VNS) of distinct axonal subpopulations modulates systemic inflammatory cytokines in an acute model of endotoxemia. A silicone spiral nerve cuff with integrated custom probes including microscale light-emitting diodes (μLEDs) was fabricated and implanted on…
Steven Oleson, Jiayue Cao, Xiaokai Wang, Zhongming Liu
The vagus nerve, the primary neural pathway mediating brain-body interactions, plays an essential role in transmitting bodily signals to the brain. Despite its significance, our understanding of the detailed organization and functionality of vagal afferent projections remains incomplete. In this study, we utilized…
Auwal Abdullahi, Thomson W. L. Wong, Shamay S. M. Ng
Cancer is globally a disease of significant public health concern owing to its prevalence, and association with morbidity and mortality. Thus, cost-effective treatments for cancer are important to help reduce its significant morbidity and mortality. However, the current therapeutic options for cancer such as…
Nicole Thompson, Svetlana Mastitskaya, Francesco Iacoviello, Paul R. Shearing + 2 more
Previous research has revealed the logical mapping of fascicles in both human somatic and pig vagus nerves, but the organization of fascicles within the human vagus nerve remains largely unknown. Understanding its fascicular arrangement would significantly advance our knowledge of the autonomic nervous system and…
Kevin P. Cheng, Sarah K. Brodnick, Stephan L. Blanz, Weifeng Zeng + 11 more
Vagal nerve stimulation (VNS) is an FDA approved treatment method for intractable epilepsy, treatment resistant depression, cluster headaches and migraine with over 100,000 patients having received vagal nerve implants to date. Moreover, evidence in the literature has led to a growing list of possible clinical…
Francesco Cerritelli, Martin G. Frasch, Marta C. Antonelli, Chiara Viglione + 3 more
'Chiara Viglione' 'Stefano Vecchi' 'Marco Chiera' 'Andrea Manzotti'] The autonomic nervous system (ANS) is one of the main biological systems that regulates the body's physiology. ANS regulatory capacity begins before birth as the sympathetic and parasympathetic activity contributes significantly to the fetus'…
Naveen Jayaprakash, Weiguo Song, Viktor Toth, Avantika Vardhan + 18 more
Vagal fibers travel inside fascicles and form branches to innervate organs and regulate organ functions. Vagus nerve stimulation (VNS) therapies activate fibers non-selectively, often resulting in reduced efficacy and side effects from non-targeted organs. Transverse and longitudinal arrangement of fibers according to…
Hugo M. Libreros-Jiménez, Jorge Manzo, Fausto Rojas-Durán, Gonzalo E. Aranda-Abreu + 7 more
The twelve cranial nerves play a crucial role in the nervous system, orchestrating a myriad of functions vital for our everyday life. These nerves are each specialized for particular tasks. Cranial nerve I, known as the olfactory nerve, is responsible for our sense of smell, allowing us to perceive and distinguish…
William J. Tyler
and Operations Authors: ['William J. Tyler'] The rapid growth of the drone industry, particularly in the use of small unmanned aerial systems (sUAS) and unmanned aerial vehicles (UAVs), requires the development of advanced training protocols for remote pilots. Remote pilots must develop a combination of technical and…
Martin G. Frasch
—Code is generally defined as a system of signals or symbols for communication. I synthesize the experimental evidence for the presence and utility of such communication in the heart rate variability (HRV): HRV contains signatures of information flow between the organs and of response to physiological or…
Kirill Aristovich, Matteo Donegà, Cathrine T. Fjordbakk, Ilya Tarotin + 7 more
'Ilya Tarotin' 'Christopher A. R. Chapman' 'Jaime Viscasillas' 'Thaleia‐Rengina Stathopoulou' 'Abbe Crawford' 'Daniel Chew' 'Justin Perkins' 'David Holder'] Background. Neuromodulation by electrical stimulation of the human cervical vagus nerve may be limited by adverse side effects due to stimulation of off-target…
Mingju Cao, Shikha Kuthiala, Keven Jason Jean, Hai Lun Liu + 7 more
'Marc Courchesne' 'Karen Nygard' 'Patrick Burns' 'André Desrochers' 'Gilles Fecteau' 'Christophe Fauré' 'Martin G. Frasch'] BACKGROUND. Glucosensing elements are widely distributed throughout the body and relay information about circulating glucose levels to the brain via the vagus nerve. However, while anatomical…
Aude Castel, Patrick Burns, Javier Benito, Hai L. Liu + 8 more
'Shikha Kuthiala' 'Lucien Daniel Durosier' 'Yael Frank' 'Mingju Cao' 'Marilène Paquet' 'Gilles Fecteau' 'André Desrochers' 'Martin G. Frasch'] Aude Castel 1 , Burns, Patrick M1 , Benito, Javier 1 , Liu, Hai L 2 , Kuthiala, Shikha 2 , Durosier, Lucien D 2 , Frank, Yael S 3 , Cao, Mingju 2 , Marilène Paquet 4 , Fecteau…
Christophe L. Herry, Patrick Burns, André Desrochers, Gilles Fecteau + 4 more
'Lucien Daniel Durosier' 'Mingju Cao' 'Andrew Seely' 'Martin G. Frasch'] Fetal heart rate variability (fHRV) is an important indicator of health and disease, yet its physiological origins, neural contributions in particular, are not well understood. We aimed to develop novel experimental and data analytical approaches…
Isabella Schapira, Lillian Russo-Savage, Terdha Narla, Maggie O'Neill + 3 more
Despite the fact that tryptophan is an essential amino acid that humans typically obtain through diet, there are several interesting tryptophan dynamics at play in the body. Quantifying and understanding these dynamics are crucial in studies of depression, autism spectrum disorder, and other disorders that involve…