22 papers · ranked by Valyu relevance
Alexander Muacevic, John R Adler, Sourik Mukherjee, Aman K Mohanty + 3 more
'Raj Kumar Chinnadurai' 'Dipayan Deb Barman' 'Abhijit Poddar'] Low- and middle-income countries (LMICs) are increasingly challenged by the rising burden of medicolegal cases. Traditional forensic infrastructure and in vivo rodent models often have significant limitations due to high costs and ethical concerns. As a…
Irene Russo, Emma Sartor, Laura Fagotto, Anna Colombo + 2 more
'Natascia Tiso' 'Mauro Alaibac'] Recently, the zebrafish has been established as one of the most important model organisms for medical research. Several studies have proved that there is a high level of similarity between human and zebrafish genomes, which encourages the use of zebrafish as a model for understanding…
Yuting Lu, E. Elizabeth Patton
Zebrafish embryos are widely used for drug-discovery however administering drugs to adult zebrafish is limited by current protocols that can cause stress. Here, we develop a drug formulation and administration method for adult zebrafish by producing food-based drug pellets which are consumed voluntarily. We apply this…
Piotr Podlasz, Marta Migocka-Patrzałek, Tomasz K. Prajsnar, Anna Sarosiak + 1 more
The zebrafish (Danio rerio) has become a widely adopted vertebrate model in biomedical research, offering high translational value while supporting the principles of Replacement, Reduction, and Refinement (3Rs). Here, the Polish Zebrafish Society presents comprehensive, field-specific recommendations for the…
Ramcharan Singh Angom, Naga Malleswara Rao Nakka, Alfredo Caturano
The zebrafish (Danio rerio) has emerged as an appreciated and versatile model organism for studying cardiovascular and metabolic diseases, offering unique advantages for both basic research and drug discovery. The genetic conservation between zebrafish and humans and their high fecundity and transparent embryos allow…
Federica Tonon, Gabriele Grassi
Belonging to the family of Cyprinidae, the zebrafish is a small freshwater fish present in the rivers of Bangladesh, Northern India and Southern Nepal [1]. Active during the day, in the wild, zebrafish feed on small aquatic invertebrates. Their use as a model organism to investigate novel therapeutic molecules as well…
José G. Ortiz, Robert Gerlai
Life on Earth started just over 3.5 billion years ago. The last common ancestor of current-day fish and mammals lived about 0.4 billion years ago. That is, the first 3.1 billion years of biological evolution are shared between these two vertebrate taxa. The result of this long common evolutionary history is that there…
Yvonne M. Bradford, Ceri E. Van Slyke, Douglas G. Howe, David Fashena + 10 more
Danio rerio is a model organism used to investigate vertebrate development. Manipulation of the zebrafish genome and resultant gene products by mutation or targeted knockdown has made the zebrafish a good system for investigating gene function, providing a resource to investigate genetic contributors to phenotype and…
Kevin Adi Kurnia, Gilbert Audira, Michael Edbert Suryanto, Tzong-Rong Ger + 1 more
Zebrafish (Danio rerio) are widely used in neurobehavioral research due to their translational relevance in studying fear. Eight different fish species and variations were tested to induce fear responses in zebrafish, including one positive control (convict cichlid, Amatitlania nigrofasciata) and negative control…
Qianghua Chen, Huiyu Wang, Li Ming, Ying Zhao
Zebrafish share a high degree of homology with human genes and are commonly used as model organism in biomedical research. For medical laboratories, counting zebrafish is a daily task. Due to the tiny size of zebrafish, manual visual counting is challenging. Existing counting methods are either not applicable to small…
Jiaheng Xie, Patrick T. Goodbourn, Bang V. Bui, Patricia R. Jusuf
Myopia is predicted to impact approximately 5 billion people by 2050, necessitating mechanistic understanding of its development. Myopia results from dysregulated genetic mechanisms of emmetropization, caused by over-exposure to aberrant visual environments; however, these genetic mechanisms remain unclear. Recent…
Andrew J. Velkey, Caroline H. Koon, Isabel A. Danstrom, Katie M. Wiens
Zebrafish (Danio rerio) share a considerable amount of biological similarity with mammals, including identical or homologous gene expression pathways, neurotransmitters, hormones, and cellular receptors. Zebrafish also display complex social behaviors like shoaling and schooling, making them an attractive model for…
C. K. Chan, Hong‐Ming Hsu
Visual Communication and Behavior Modulation Authors: ['C. K. Chan' 'Hong‐Ming Hsu'] Motions of visually coupled zebrafish pairs are studied to understand the effects of visual information exchange on their behavior as a function of their minimal separation (d). We find that when d is small, the pair can display a…
Hong Ye, Xin Xu, Jixiang Wang, Jing Wang + 3 more
'Guohua Shi'] Abstract: Light-sheet fluorescence microscopy (LSFM) makes use of a thin plane of light to optically section and image transparent tissues or organisms in vivo, which has the advantages of fast imaging speed and low phototoxicity. In this paper, we have employed light-sheet microscopy to investigate the…
Bryan James, Alexander Medvedev, Sergei Makarov, Robert Nelson + 2 more
Popularized on social media, hand-moldable plastics are formed by consumers into tools, trinkets, and dental prosthetics. Despite the anticipated dermal and oral contact, manufacturers share little information with consumers about these materials. Inherent to their function, moldable plastics pose a risk of dermal and…
Authors not listed
The development of effective neurological treatments remains a challenge due to the low permeation across the blood-brain barrier (BBB). The use of nanoparticles for brain drug delivery is promising, but the level of BBB crossing remains low, typically around 0.5-3%. We report the synthesis of negatively charged…
Heng Li, Wanting Zhang, Keyi Ren, Hong Yang + 6 more
In terms of the utilization of omics data, the current fish database analysis functions are primarily relatively simple tools at the transcriptional level, aimed at obtaining the co-expression levels of specified genes or the data visualization of multiple genes, and do not enable users to perform comprehensive omics…
Clifford Rostomily, Heidi Lee, Amy Tresenrider, Riza M. Daza + 4 more
zebrafish embryos for single-nucleus RNA sequencing Authors: ['Clifford Rostomily' 'Heidi Lee' 'Amy Tresenrider' 'Riza M. Daza' 'Andrew R. Mullen' 'Jay Shendure' 'David Kimelman' 'Cole Trapnell'] Zebrafish are an ideal system to study the effect(s) of chemical, genetic, and environmental perturbations on development…
Claudius F. Kratochwil, Muktai Kuwalekar, Jan Haege, Nidal Karagic
At the core of most research in zoological disciplines, ranging from developmental biology to genetics to behavioral biology, is the ability to keep animals in captivity. While facilities for traditional model organisms often benefit from well-established designs, construction of a facility for less commonly studied…
Kirsten L. Underwood, Whitney J. Walker, Patrick I. Garrett, Shannon Linch + 2 more
Zebrafish are an increasingly popular model to study spinal cord injury (SCI) regeneration. The transparency of larval zebrafish makes them ideal to study cellular processes in real time. Standardized approaches, including age of injury, are not readily available making comparisons of the results with other models…
Raja Mohanrao, Clyde S. Pinto, Andrejus Suchenko, Guy J. Clarkson + 4 more
A series of clickable single-benzene-based fluorophores derived from tetrafluoroterephthalonitrile (4F-2CN) is reported. Fluorophores based on a tetrahydroquinoxaline skeleton (2F-2CN-(β-NH2Ala)) exhibited improved photophysical properties owing to better planarity and conjugation over those with dihydro[1,4]thiazine…
Erika Fodor, Javan Okendo, Nóra Szabó, Kata Szabó + 11 more
Over the decades, a small number of model species, each representative of a larger taxa, have dominated the field of biological research. Amongst fishes, zebrafish (Danio rerio) has gained popularity over most other species and while their value as a model is well documented, their usefulness is limited in certain…